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CRISPR Cas9

Total questions: 9

Worksheet time: 5mins

Name
Class
Date
1.

CRISPR-Cas9 is a type of ________ system found in bacteria.

a)

digestive

b)

endocrine

c)

circulatory

d)

immune

2.

CRISPR-Cas9 was discovered in which of the following organisms?

a)

protists

b)

fungi

c)

bacteria

d)

viruses

3.

Scientists have adapted it to turn it into a biotechnology tool for _______ DNA.

a)

building

b)

editing

c)

destroying

d)

synthesizing

4.

The enzyme portion of this complex is called ________.

a)

CRISPR

b)

Replicase

c)

Lysozyme

d)

Cas9

5.

What type of RNA is used as a GPS of sorts, to find or locate specific genes?

a)

mRNA

b)

gRNA

c)

tRNA

d)

rRNA

6.

What is PAM?

a)

a 3 letter sequence for binding on the target DNA

b)

the main gene portion of the DNA

c)

the cut site for Cas9

d)

a 10 letter sequence for binding on the target DNA

7.

Once the DNA and RNA are bound, Cas9 is activated to cut the DNA ____ upstream from the binding sequence.

a)

1 base

b)

3 bases

c)

6 bases

d)

10 bases

8.

After Cas9 cuts the target DNA, cellular enzymes attempt to repair the break. Which of the following types of repair mechanisms creates a mutation and inactivates the gene.

a)

HDR

b)

NHEJ

9.

After Cas9 cuts the target DNA, cellular enzymes attempt to repair the break. Which of the following repair mechanisms involves "editing" of the gene with insertion of a corrected sequence?

a)

HDR

b)

NHEJ