Hormonal Contraceptives

Contraceptive failure has been observed

Hormonal Contraceptives

Long-term administration of large doses of __________ prevents the periodic breakdown of the endometrial tissue and in some cases will lead to endometrial fibrosis

Hormonal Contraceptives

• Subcutaneous progestin implant capsule

• Also used in some oral contraceptives

Hormonal Contraceptives

• Aka morning after contraception

• Often administered with antiemetics

• Other adverse effects include headache, dizziness, breast tenderness, and abdominal and leg cramps

• Mifepristone

Pharmacologic Effects of Hormonal Contraception

• Chronic use of combination agents depresses ovarian function

• Ovaries usually become ________

Pharmacologic Effects of Hormonal Contraception

• Majority of patients return to normal menstrual patterns when these drugs are discontinued

Pharmacologic Effects of Hormonal Contraception Combination agents containing 19- norprogestins (particularly those with smaller amounts of estrogen) produce:

• Increased glandular atrophy

• ______ bleeding

Pharmacologic Effects of Hormonal Contraception

• __________ lactation

Pharmacologic Effects of Hormonal Contraception

• Increase excitability in the brain

• Used in premenstrual tension syndrome, postpartum depression, and climacteric depression

Pharmacologic Effects of Hormonal Contraception

• Decrease excitability in the brain

• Has thermogenic action

Pharmacologic Effects of Hormonal Contraception

• _______ in serum iron and total iron binding capacity

Pharmacologic Effects of Hormonal Contraception

• _______ serum haptoglobulins

Pharmacologic Effects of Hormonal Contraception

• Rate of GI absorption of carbohydrates

• Reversible carbohydrate tolerance (in long-term use of potent progestins such as norgestrel)

Pharmacologic Effects of Hormonal Contraception

• Basal insulin level

• Insulin rise induced by carbohydrates

Pharmacologic Effects of Hormonal Contraception

• Cardiac output

• SBP

• DBP

• Heart rate