WorksheetsAntiamoebic and antihelmenthic drugs
Total questions: 20
Worksheet time: 10mins
A 34-year-old woman complained of itching and burning around her vagina and a foulsmelling vaginal discharge. A wet mount examination of the discharge showed pear-shaped trophozoites that exhibited jerky motility. Which of the following drugs would be appropriate for this patient?
Sulfadoxine
Terbinafine
Metronidazole
Fluconazole
Amoebiasis is caused by
TOxoplasma Gondii
Entamoeba Histolytics
Ascaris Lumbricoidis
None of these
Amoebiaisis causes
Headache and cold
Dysentery
Fever
Weight Gain
Metronidazole is acts as
Luminal amoebicidal
Extraintestinal amoebicidal
intestinal and extraintestinal amoebicidal
none of the above
Which of the following antiprotozoal agent used in the treatment of malaria as well as amoebiasis
pyrimethamine
Proguanil
prontosil
Chloroquine
For optimum antiamoebic activity, ______ numbered carbon alkyl chain at N-1 position of imidazole moiety
2
1
3
4
Mechanism of Metronidazole
Nitro group reduced to highly reactive radical that damages DNA
Disrupts energy metabolism
both
None of the above
NitroImidazoles (Metronidazole) are contraindicated in
First trimester of pregnancy
Blood dyscarsia
Chronic alcoholism
Neurological Diseases
all of the above
Mechanism of emetine
directly kill trophozoites
inhibit protein synthesis in amoeba
both
none of the above
Diloxanide furoate mechanism
directly kills cysts
directly kills trophozoites responsible for production of cysts
targets heamoglobin
none of the above
The site of
action of mebendazole
mitochondria of the parasite
microtubular protein ‘β-tubulin’ of the parasite
cell wall
lysosome
Pyrantel pamoate causes
hyperpolarization of Ascaris muscle by a
GABA agonistic action opening Cl¯ channels
alteration of Mf membranes
activation of nicotinic
cholinergic receptors in the worms resulting in
persistent depolarization
None of the above
Muscular
activity of the Microfilaria and adult worms is also affected causing hyperpolarization due to the piperazine
moiety of DECC, so that they are dislodged.
true
false
how to treat febrile reaction with rash, pruritus, enlargement of lymph nodes and fall in BP produced after DiEthyl Carbamazine Citrate administration
DEC should be
temporarily withheld
antihistaminics given
corticosteroids given
all of the above
Nematodes develop tonic paralysis when
exposed to ivermectin
through a special
type of glutamate gated Cl¯ channel
GABA gated Cl channel
NMDA gated ca channel
none of the above
drug of
choice for single dose treatment of onchocerciasis
and strongyloidosis
Ivermectin
DECC
Mebendazole
metronidazole
Drug of choice for Wuchereria Bancrofti and Brugia Malayi
Diethyl carbamazine, Ivermectin
Praziquantel, Pyrental
Praziquantel, Niclosamide
None of the above
Incidents of expulsion of Ascaris
from mouth or nose have occurred with
Ivermectin
DECC
Praziquantel
mebendazole
antibiotics useful in amoebiasis
Penicillin
tetracyclin
cephalosporin
polymixin
factors in the spread of the Amoebiasis
Air contamination
faecal contamination of food and
water.
both
none of the above
