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CBL N - Week 42

Total questions: 18

Worksheet time: 22mins

Name
Class
Date
1.

A 20 y/o African American male presents to the ED with left-sided flank pain and hematuria. He has been hospitalized twice for pain crises and his father had a stroke at age 30. The renowned hematologist Dr. Jam Allenovich is asked to consult. He sends the patient for a CT to rule out ____.

a)

Wilms Tumor

b)

Clear Cell RCC

c)

Renal Medullary Carcinoma

d)

Angiomyolipoma

2.

Which association is incorrect?

a)

Clear Cell RCC, von-Hippel-Lindau Disease

b)

Chromophobe RCC, Birt-Hogg-Dube Syndrome

c)

Angiomyolipoma, tuberous sclerosis

d)

Wilms tumor, trisomy of chromosome 7

3.

Find the FALSE statement.

a)

In metabolic acidosis, HCO3- is completely reabsorbed and the excess H+ is buffered by phosphate, other organic anions, and ammonia and excreted.

b)

Intercalated cells in distal tubule and collecting duct employ hydrogen potassium exchanger ATPase to secrete H+ against its concentration gradient.

c)

When H+ is secreted from proximal tubule via non-bicarbonate buffers, there is addition of new HCO3- to the blood.

d)

In compensated metabolic acidosis, the kidney is unable to reabsorb all the HCO3- from urine because H+ is not secreted excessively due to compensation.

e)

NH4+ must be excreted in urine for net gain of HCO3-.

4.

Why do mountain climbers take Diamox?

a)

Diamox increases bicarbonate reabsorption and prevent metabolic acidosis by supplying more bicarbonate to their system.

b)

It prevents hyperventilation by decreasing pCO2.

c)

It gives a mild acidosis which helps drive respiration to prevent hypoxemia despite low pCO2.

d)

They have taste disturbance when drinking carbonated beverages due to altitude sickness.

5.

A 39 year old male presents to the clinic for a 2-week history of coughing with blood-tinged sputum. He also reports difficulty urinating. Labs were obtained and showed creatinine levels of 1.8 mg/dL. Urinalysis showed low volume, dark colored urine with red blood cell casts and protein levels of 1.9 g/day. CT scan shows diffuse alveolar hemorrhage. What additional findings are likely to be found?

a)

Positive anti-GBM antibodies

b)

Double glomerular basement membrane on renal biopsy

c)

Subepithelial humps on electron microscopy

d)

Negative immunofluorescent staining

e)

Apple-green birefringence on Congo red staining

6.

Which of the following treatments is not indicated in various etiologies of rapid progressive glomerulonephritis?

a)

Prednisone

b)

Cyclophosphamide

c)

Furosemide

d)

Plasmapheresis

e)

None of the above

7.

Dr. King-Author’s-Court-Bend-the-Knee SugarRay-Sahara is reviewing some of her patient’s charts. Which of the following profiles should raise the greatest concern for progressing to an invasive stage (select ALL that apply).

a)

Small urothelial <1.0cm tumors, exophytic histology with 7 outer layers, and fibrovascular core

b)

Urothelial exophytic tumor with more than 7 outer layers, mitotic figures, FGFR3 mutation

c)

Urothelial exophytic tumor with more than 7 outer layers, mitotic figures, TP53 and RB mutation

d)

Urothelium with marked nuclear atypia, and loss of normal polarity. Normal submucosa and muscularis

8.

Dr. Jor’el-of-Krypton Fongiformhistology is reviewing for his oncology boards. He is asked to select from each of the following pairs which side is worse? (enter each pair choice separated by a comma. i.e. A, C, E, G, I)


A-Transition zone Prostate enlargement

or

B – Peripheral zone prostate enlargement

________________________________________________

C-Positive Basal Cell Markers on IHC

or

D- Negative Basal Cell Markers on IHC

________________________________________________

E-Asymptomatic Prostate enlargement

or

F-Symptomatic prostate enlargement

________________________________________________

G- PSA of 4.5 (normal is <4.0)

or

H - PSA of 2.5 that is now 3.9 (Normal is<4.0)

________________________________________________

I – Gleason grade 5

or

J – Gleason score 6

(a)  

9.

1. A 59-year-old lactose intolerant (get it together!) man named Darrell Dang (don’t come for me I tried my best!) comes to the clinic and reports increasing lethargy, weakness, and bony pain over the past 2 years. During this time, he has been urinating 12-15 times per day and describes his urine as yellow and frothy with no traces of blood. History reveals a pathologic hip fracture 1 year ago. X-ray studies show several small, hypodense lesions in the hip and spine. Further tests show a serum protein concentration of 9 g/dL, and serum protein electrophoresis yields increased gamma globulins. The physician decides to order a kidney biopsy. Which of the following glomerular findings is most likely?

a)

Destruction of glomeruli with crescents of proliferating cells adherent to Bowman’s capsule

b)

Fibrillary deposits in the mesangium and subendothelium that stain positive with Congo red

c)

Focal lesions involving collapse of the basement membrane, increase in matrix, and deposition of hyaline masses, with detachment of the epithelial cells from the basement membrane

d)

Normal appearance under light microscopy but with podocyte foot effacement under electron microscopy

10.

1. A 52-year-old man presents to Brian “In the Bones?!” Basden’s clinic for a routine follow-up appointment. The patient has advanced chronic kidney disease due to focal segmental glomerulosclerosis. He feels well but notes his bones have been “more achy than usual.” On physical examination, tapping over the cheek elicits a facial muscle spasm. Laboratory tests show an elevated serum parathyroid hormone (PTH) level. Which of the following sets of laboratory values is most likely to be seen in this patient?

a)

A

b)

B

c)

C

d)

D

e)

E

11.

A cachectic medical student, who pretends to be married and a father, and was 6-months-old during the genocidal Sabra and Shatilla massacre, presents to your clinic hypoxic at 93 and tachycardic at 103. Temp = 37 degrees Celsius on acetaminophen (1400 mg that day), RR=18, CBC WNL, dry oral mucosa, with auscultation of the lungs concerning for lobar pneumonia. SIRS (systemic inflammatory response syndrome) = 1 (from heart rate) and MAP = 78. What concern do you have for sepsis?

a)

moderate concern, SIRS positive with a likely source

b)

little to no concern, SIRS negative, normal MAP

c)

moderate to high level of concern, likely source + abnormal MAP + hypoxia and tachycardia

d)

moderate concern, while SIRS is negative, it is an imperfect screening tool (remember qSOFA and esp. lactate are better at predicting mortality than SIRS [true story])

12.

You have dreams about microorganisms followed by

catheterized armadillos. First you see gram positive chains, then a rash that spreads from the hands and feet centripetally, then an antigen that crosslinks TCR-beta and MHC-II of an APC, a non-inflammatory process, vasculitis, colon cancer, then edema toxin+lethal toxin. You dreamed about what 7 things in this order?

a)

Clostridum ssp. → R. rickettsiiS. aureus → gas gangrene → Ricketsia ssp. → C. septicumB. anthracis

b)

Bacillus ssp. → R. rickettsiiS. aureus → gas gangrene → Ricketsia ssp. → C. septicumB. anthracis

c)

Bacillus ssp. → R. rickettsiiB. anthracis → gas gangrene → Ricketsia ssp. → C. septicumS. aureus

13.

Have you guys heard of that tiktok trend where it’s like, take all the vowels in your name and replace them with “oob”? No? Whatever. Anyway, Dr. Coobrtnooboob Soobgoobhoobroob has to calculate somebody’s net filtration pressure. There’s no funny story because that name took all of my creative energy. How is the net filtration pressure calculated, given the glomerular hydrostatic pressure, bowman’s capsule pressure, and the glomerular oncotic pressure?

a)

NFP = GHP + BCP – GOP

b)

NFP = GPH*BCP/GOP

c)

NFP = GHP + BCP + GOP

d)

NFP = GHP – BCP – GOP

14.

Dr. Noobkhoobl Goobngoobsoobnoob has a patient with Addison’s disease. The patient does not understand garden hose hydrodynamics, so they ask Dr. Goobngoobsoobnoob if that means that, during an Addisonian crisis, the efferent arterioles of their glomeruli have lower or higher pressure than those of someone with similar physiology except without Addison’s disease. Dr. Goobngoobsoobnoob is a cardiologist, not a nephrologist, so please help him answer that question:

a)

No, the patient’s afferent arterioles would have lower blood pressure, so that means the efferent arterioles would have higher blood pressure as a result

b)

Yes, the patient’s afferent arterioles would have lower blood pressure, so that means the efferent arterioles would have lower blood pressure as a result

c)

Yes, the patient’s afferent arterioles would have higher blood pressure, so that means the efferent arterioles would have lower blood pressure as a result

d)

No, the patient’s afferent arterioles would have higher blood pressure, so that means the efferent arterioles would have higher blood pressure as a result

15.

Dr. Joobrroob Foobng is sitting in CJ at midnight one night, playing chess instead of studying, when suddenly the Ghost of Step Exams Past appears in front of him. “I am the Ghost of Step Exams Past,” said the Ghost of Step Exams Past. “Your CBL friends always make fun of you for being lactose intolerant, right? I can offer you a deal: I will take away your lactose intolerance and give you diabetes instead.” “That doesn’t sound good, and anyway I don’t trust you because I’ve never heard of a ghost who offers deals like that,” said Dr. Foobng. “Well, I’ve never heard of a 24 year old man with an RA, and here you are,” snapped the Ghost of Step Exams Past. “But think about it, if you had diabetes, then some of your glucose would be excreted in your urine instead of being reabsorbed by your ascending loop of Henle! Wouldn’t that be nice?” What is wrong with what the Ghost of Step Exams Past said (scientifically, not morally)?

a)

Glucose is reabsorbed in the proximal tubule, not the ascending loop of Henle

b)

Glucose is supposed to be excreted in the urine, not reabsorbed at all

c)

Glucose is reabsorbed in the distal tubule, not the ascending loop of Henle

d)

Glucose does not have to be reabsorbed because it never enters the kidney

16.

Dr. Brooboobn Boobsdoobn (this is the best one) made a bunch of flashcards to learn what the different parts of the nephron do. His adorable son came along and shuffled the flashcards, but somehow did so in a way that the actual terms and definitions got mixed around, which shouldn’t be possible, but that’s exactly what happened. Please put the numbered terms in order so that they match the characteristics listed. (list numbers separated by commas)

(a)  

17.

An adolescent Danny Fangtom comes to the physician’s office with 24 hours of leg swelling and dark urine. He had a sore throat and fever 2 days ago. Current blood pressure is 130/92 mm Hg. Physical examination shows edema in both ankles. Subsequent urinalysis shows hematuria, RBC casts, and proteinuria of 2.5 g/day. Serum complement level is normal.


Which of the following is most likely to be found on microscopic evaluation of a renal biopsy?

a)

Dense deposits within the basement membrane

b)

Mesangial immune deposits

c)

Podocyte effacement with otherwise normal glomeruli

d)

Subendothelial basement membrane deposits

e)

Subepithelial humps

18.

A 56-year-old woman comes to the clinic because of swollen legs for several days. Urinalysis shows 4+ proteinuria; serum albumin concentration is 2.9 mg/dL. Renal biopsy shows findings as shown in about 40-50% of the glomeruli.

a)

Hepatitis C

b)

Streptococcal infection

c)

Lymphoma

d)

Nonsteroidal anti-inflammatory drug use

e)

Injectable drug use