WorksheetsHHMI Sex Verification of Athletes - Case Studies
Total questions: 12
Worksheet time: 6mins
Here are the results of the sprinter’s physical exam.
If you were one of the judges in 1966, would you rule that the athlete is eligible to compete in women's events? Select your answer below.
Eligible
Not eligible
Here are the sprinter’s Barr body test results.
If you were one of the judges in 1968, would you rule that the athlete is eligible to compete in women's events?
Eligible
Not eligible
Here is an image of the gel for the sprinter.
If you were one of the judges in 1992, would you rule that the athlete is eligible to compete in women's events?
Eligible
Not eligible
Here is the testosterone measurement for the sprinter.
If you were one of the judges in 2011, would you rule that the athlete is eligible to compete in a women's event?
Testosterone level: 25 nmol/L
Eligible
Not eligible
These are all of the sprinter's test results.
Based on the data, how would you characterize this athlete's biological sex?
Female
Male
I don't know
Which of the following genetic variations could result in an individual who has female external reproductive anatomy and secondary sex characteristics, but also appears to have a functioning SRY gene and high testosterone level?
46,XX individual with a genetic mutation that results in more testosterone being produced
45,X individual with only one X chromosome and no Y chromosome, and a mutation in a gene that results in more testosterone being produced
46,XY individual with a mutation that inactivates the androgen receptor (AR) gene, resulting in androgen insensitivity
46,XY individual with a mutation that inactivates the SRY gene so that the testes do not develop
Here are the results of the swimmer’s physical exam.
If you were one of the judges in 1966, would you rule that the athlete is eligible to compete in women's events? Select your answer below.
Eligible
Not eligible
Here are the swimmer’s Barr body test results.
If you were one of the judges in 1968, would you rule that the athlete is eligible to compete in women's events?
Eligible
Not eligible
Here is an image of the gel for the swimmer.
If you were one of the judges in 1992, would you rule that the athlete is eligible to compete in women's events?
Eligible
Not eligible
Here is the testosterone measurement for the swimmer.
If you were one of the judges in 2011, would you rule that the athlete is eligible to compete in a women's event?
Testosterone level: 3 nmol/L
Eligible
Not eligible
These are all of the swimmer's test results. Based on the data, how would you characterize this athlete's biological sex?
Female
Male
I don't know
Which of the following genetic conditions could result in an individual who has many secondary sexual characteristics typical of a female, no SRY gene, and low testosterone levels, but appears to have only one X chromosome?
46,XX individual with a mutation in a gene that results in high levels of testosterone being produced
45,X individual with only one X chromosome and no Y chromosome, and a mutation in a gene that results in high levels of testosterone being produced
46,XY individual with a mutation that inactivates the androgen receptor (AR) gene, resulting in androgen insensitivity
46,XY individual with a mutation that inactivates the SRY gene so that the testes do not develop
