A 7-year-old boy presents to the clinic with fever and maculopapular rashes. Based on the laboratory investigations a diagnosis of measles is made.

Which of the following is the most appropriate test to confirm the diagnosis in this patient?

A 15-year-old boy presents to the Emergency Department with complaints of fever, pain in his left tibia. He recalls, two days ago hurting his leg during a soccer match. His left leg is warm and swollen on physical examination. Based on the laboratory investigations a diagnosis acute osteomyelitis is made.

Which of the following laboratory investigations is the most appropriate in the diagnosis of this condition in this case?

A 10-year-old boy presents with a painful bony lesion in the right lower extremity. Radiograph shows a 5.6 cm expansile mass in the diaphyseal region of the right femur. Biopsy of the mass shows features of malignant “small, blue, round cell tumour”. Karyotypic analysis of the tumour cells show characteristic translocation: t (11;22).

Which one of the following bone tumours best fits with the above description?

Duchenne muscular Dystrophy (DMD) is caused by mutations that disrupt the function of dystrophin. Which of the following types of mutations most commonly occur in this disease?

A 56-year-old male presents with a skin lesion of size 5 cm on left thigh of 6-month duration. The lesion has colour varying from black to brown and red. Its borders are irregular. He also has left inguinal lymphadenopathy. A biopsy from the lesion shows sheets of large cells with prominent cherry red nucleoli and high mitotic count.

Which of the following skin lesions is the most likely diagnosis in this patient?

A 58-year-old male presents with worsening pain in right knee joint for the past 2 years. Physical examination reveals joint crepitus and restriction of movements of left knee joint. X-ray of knee shows narrowing of joint space due to loss of articular cartilage. He is diagnosed with osteoarthritis.

Which of the following processes is most likely leading to loss of articular cartilage in this patient?

A 32-year-old man diagnosed with osteosarcoma of right proximal humerus. He is started with chemotherapy consisting of combination drugs including an alkylating agent.

Which of the following anticancer drugs best describe the mode of action of the above-mentioned drug class?

A 65-year-old man with history of gouty arthritis presents for follow-up. Earlier he is successfully treated with oral anti-inflammatory drugs. Laboratory studies following his last episode showed an elevated uric acid level and normal renal function. A 24-hour urine collection showed normal excretion of uric acid.

Which of the following drugs is most appropriate to treat this patient now?

A 16-year-old boy is a diagnosed with acute osteomyelitis 10 days after injuring his lower left thigh during a high school football game. X-rays of the left femur indicate soft tissue swelling without any obvious abnormalities of the bone. Blood culture is positive for Methicillin Resistant Staphylococcus aureus. He is immediately started with intravenous antimicrobials together with drugs for symptomatic relief.

Which of the following antimicrobials is most appropriate to be administered in this patient?