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Medicinal Chemistry

Total questions: 12

Worksheet time: 10mins

Name
Class
Date
1.

Name the linkage (or) bridge present in the structure of Artemisinin?

a)

Ester

b)

Peroxide

c)

Epoxide

d)

Glycosidic linkage

2.

Pyrimethamine has the following IUPAC name:

a)

2, 4-diamino-6-ethyl-5-(p-chlorophenyl) pyrimidine

b)

2, 4-diamino-6-ethyl-5-(p-chlorophenyl) pyridine

c)

2, 4-diamino-6-ethyl-5-(m-chlorophenyl) pyrimidine

d)

2, 4-diamino-6-ethyl-5-(o-chlorophenyl) pyrimidine

3.

Isoniazid inhibits the mycolic acid synthesis by acting on which enzyme ?

a)

DNA dependent RNA Polymerase

b)

DNA gyrase

c)

Mycolase synthatase

d)

RNA polymerase

4.

1. At which position carboxylic acid functional group is present in fluoro quinolones?

a)

2

b)

5

c)

4

d)

3

5.

Iodoxuridine chemically is -----------

a)

2’-Deoxy-5-iodoxuridine

b)

3’-Deoxy-5-iodoxuridine

c)

2’-oxy-5-iodoxuridine

d)

3’-oxy-5-iodoxuridine

6.

Which element is present in the Foscarnet structure?

a)

Ferrous

b)

Fluorine

c)

Phosphorous

d)

Sulphur

7.

Which nitro imidazole derivative has morpholino moiety?

a)

Tinidazole

b)

Ornidazole

c)

Timorazole

d)

Metronidazole

8.

IUPAC name for metronidazole is

a)

2-(2-methyl-5-nitro-1H-imidazol-1-yl)- methanol

b)

2-(2-methyl-5-nitro-1H-imidazol-1-yl)- ethanol

c)

2-(2-nitro-5-methyl-1H-imidazol-1-yl)- methanol

d)

2-(2-nitro-5-methyl-1H-imidazol-1-yl)- ethanol

9.

The raw material used for the synthesis of diethyl carbamazine is

a)

Toulene

b)

N- methyl Piperazine

c)

3,4,5 – trimethoxy benzaldehyde

d)

N- methyl Pyridine

10.

Heterocyclic system present in Diethyl carbamazine is

a)

Piperazine

b)

Piperidine

c)

Pyrrolidine

d)

Pyridine

11.

The ratio of sulphamethoxazole and trimethoprim in Co-trimoxazole.

a)

1:2

b)

2:1

c)

1:5

d)

5:1

12.

Sulfasalazine is beneficial in ulcerative colitis. Which is responsible for this action? Identify.

a)

Sulfasalazine

b)

Its metabolic product, sulfapyridine

c)

Its metabolic product, amino salicyclic acid

d)

Any of the above