Which of the following is TRUE about malignant tumors? (Riggs quiz)

Cancer arising in ductal or glandular epithelial tissue: (Riggs quiz)

n the TNM staging system, M refers to tumor: (Riggs quiz)

Imaging tumors by visualizing glucose utilization can be accomplished by: (Riggs quiz)

Cancer metastasis to the bone may present as: (Riggs quiz)

Genes that have acquired a mutation that has turned the gene "ON" and increased cell proliferation: (Riggs quiz)

Genes that can be mutated to "OFF" and can lose the ability to limit cell proliferation: (Riggs quiz)

Vincristine is a cell-cycle specific anti-tumor drug because it causes mitotic arrest in this phase of the cell cycle: (Riggs quiz)

Compounds that crosslink DNA by adding an alkyl group to the guanine base of DNA: (Riggs quiz)

Drugs that block the conversion of folic acid to its active form reducing the amount required for several biochemical reactions (nucleotides) are called: (Riggs quiz)

Drugs that are analogs of cytosine, thymine and uracil-bases and ultimately block DNA synthesis are: (Riggs quiz)

Drugs that are analogs of adenine, guanine, and hypoxanthine (bases for biosynthesis of nucleic acids) and ultimately affect DNA synthesis are called: (Riggs quiz)

These drugs have mechanisms of action that include DNA intercalation and generation of DNA damaging reactive oxygen species: (Riggs quiz)

Drugs that inhibit mitosis, or cell division through the disruption of microtubules are called: (Riggs quiz)

Drugs that block enzymes that normally function to untangle the DNA helix during replication are called: (Riggs quiz)

Which of the following is an alkylating agent? (Riggs quiz)

Which of the following is a folic acid analog? (Riggs quiz)

Which of the following is a purine analog? (Riggs quiz)

Which type of anti-tumor drug is doxorubicin? (Riggs quiz)

Paclitaxel inhibits tumor growth by: (Riggs quiz)

Two mechanism to inhibit the proliferation of estrogen receptor positive breast cancer are: 1) starve the tumors of estrogen and 2) block the ability of estrogen receptor to function in the cell. (Riggs quiz)

Aromatase inhibitors function to: (Riggs quiz)

Tamoxifen functions to: (Riggs quiz)

Which drug is an antibody blocks the ability of tumor cells to block activation of programmed cell death 1 (PD-1) receptor and therefore allows immune recognition of tumor cells? (Riggs quiz)

Paclitaxel is a cell-cycle specific anti-tumor drug because it activates the mitotic checkpoint at what stage(s) of the cell cycle:

Which drugs are antimetabolites

Etoposide inhibits tumor growth by:

Paclitaxel inhibits tumor growth by:

These anti-cancer drugs work by generating ROS:

These anti-cancer drugs are cell-phase non-specific:

These anti-cancer drugs are cell-phase specific:

Tamoxifen only works on estrogen positive tumors

cancer

tumor: abnormal growth resulting from _______ proliferation and serves no physiological function

cancers arising in epithelial tissue

cancer arising from connective tissue

cancer of lymphatic tissue

cancer of blood forming cells

Carcinoma in situ (CIS) lesions can have what three possible fates:

In TNM Staging System, ___ represents the number of nearby lymph nodes that contain cancer cells

In TNM Staging System, ___ represents the size and extent of the main (primary) tumor

Cancer cells, unlike most normal cells

RAS is an example of

Retinoblastoma is an example of

Antimetabolites are cell-phase specific drugs, most commonly ___ phase.

Which of the following is a platinum compound?