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Cell Injury 2

Total questions: 10

Worksheet time: 9mins

Name
Class
Date
1.

Activation of which of the following enzymes will induce increased mitochondrial membrane permeability by forming pores on its membrane?

a)

Bcl-xL & Bcl-w

b)

Bax & Bak

c)

Mcl-1

d)

FADD

2.

Which of the following is a sign of reversible cell injury?

a)

necrosis

b)

hydrophic change

c)

apoptosis

d)

metaplasia

3.

Which of the following will occur in both apoptosis and atrophy?

a)

an adaptive response to stressors.

b)

involves a decrease in cell size.

c)

nuclear fragmentation occurs.

d)

a passive process that does not require energy

4.

Which of the following will differentiate necrosis from hypertrophy? Necrosis...

a)

involves enlargement of the cell.

b)

may be due to a physiologic or pathologic cause.

c)

almost always activate inflammation.

d)

involves disruption of the cell's membranes

5.

A tissue preparation is experimentally subjected to a hypoxic environment. The cells in this tissue begin to swell, and chromatin begins to clump in cell nuclei. ATPases are activated, and ATP production decreases. Which of the following ions accumulating in mitochondria and the cytosol contributes most to these findings and to eventual cell death?

a)

Ca2+

b)

Cl-

c)

K+

d)

Na+

e)

PO4 3-

6.

An 11-year-old girl becomes infected with hepatitis A and experiences mild nausea for 1 week. On physical examination, she has minimal right upper quadrant tenderness and yellowish sclera. Laboratory findings showed elevated liver enzymes. Her laboratory findings most likely result from which of the following

changes in her hepatocytes?

a)

cell membrane defect

b)

mitochondrial swelling

c)

ribosomal dispersion

d)

ER swelling

e)

nuclear chromatin clumping

7.

A 72-year-old man died suddenly from congestive heart failure. At autopsy, his heart weighed 580 g (normal 330 g) and showed marked left ventricular hypertrophy, minimal coronary arterial atherosclerosis and calcium deposits on the cusps his aortic valve. Which of the following pathologic processes best accounts for the changes in his aortic valve?

a)

hemosiderosis

b)

metastatic calcification

c)

hyaline change

d)

dystrophic calcification

e)

Lipofuscin deposition

8.

A 68-year-old woman suddenly lost consciousness and on awakening 1 hour later, she could not speak or move her right arm. Two months later, a head CT scan showed a large cystic area in the left parietal lobe. Which of the following pathologic processes has most likely occurred in her brain?

a)

Apoptosis

b)

Liquefactive necrosis

c)

Coagulative necrosis

d)

Fat necrosis

e)

Fibrinoid necrosis

9.

A 63-year-old man has a 2-year history of worsening congestive heart failure. An echocardiogram shows mitral valve stenosis with left atrial dilation. A mural thrombus is present in the left atrium. One month later, he experiences left flank pain and notes hematuria. Embolization of the thrombus has likely led to blockage of a renal arterial branch, causing what type of necrosis in this patient?

a)

Caseous

b)

Coagulative

c)

Fat

d)

Gangrenous

e)

Liquefactive

10.

Which of the following mechanisms contribute to cellular aging?

a)

calorie restriction

b)

telomere shortening

c)

defective DNA repair

d)

abnormal protein homeostasis

e)

all of these