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1.3.1 DNA Detectives

Total questions: 14

Worksheet time: 21mins

Name
Class
Date
1.

In Part I DNA Digestion with Restriction Enzymes

If I'm going to do a 30-60 minute restriction digestion, what temp should my water bath be?

a)

37 degrees C

b)

45 degrees C

c)

37 degrees F

d)

45 degrees F

2.

In Part I DNA Digestion with Restriction Enzymes

How many tubes does your team need to label for this lab?

a)

1

b)

2

c)

3

d)

4

3.

In Part I DNA Digestion with Restriction Enzymes

What do you add to your tubes RIGHT BEFORE freezing them?

a)

SYBRSafe

b)

10x gel loading dye (solution)

c)

enzyme

d)

DNA

4.

In the gel making video, when making a 30 ml gel, what mass of agarose powder should be added to the buffer to make the gel?

a)

0.24g

b)

0.48g

c)

.008g

d)

24g

5.

In Part I DNA Digestion with Restriction Enzymes

How much Enzyme 1 will you need TOTAL for this lab (this includes for both Missing Person 1 and Missing Person 2)

a)

15 microliters

b)

25 microliters

c)

30 microliters

d)

45 microliters

6.

What's the purpose of adding the restriction enzymes to your sample? (Remember what restriction enzymes do from the Bozeman Video)

a)

they'll separate the DNA bases

b)

they'll copy the DNA

c)

they'll cut the DNA

d)

they'll make the DNA glow

7.

From your gel making video notes, what role will SYBR Safe play in this lab?

a)

It will make the DNA strands move

b)

It will make the DNA strands separate

c)

It will copy the DNA strands

d)

It will make the DNA strands visible

8.

From the gel making video, why do we wrap the gel in aluminum foil after making it?

a)

to prevent light from damaging the stain

b)

to keep it moist

c)

to allow the DNA strands to be copied

d)

to hide it from other teams

9.

What's the purpose of gel electrophoresis?

(Check your Bozeman Video notes)

a)

to make the DNA visible

b)

to separate the pieces of DNA

c)

to tag the DNA pieces with color

d)

to copy the pieces of DNA

10.

Part 2 Gel Electrophoresis of Restriction Enzymes

When loading your gel, what should go into lane 6?

(MP=Missing Person, E=Enzyme)

a)

MP 1 cut with E1

b)

MP 1 cut with E2

c)

MP 2 cut with E1

d)

MP 2 cut with E2

11.

In the Gel Loading Video, which well comb should you use when making your gel?

a)

6 wells

b)

8 wells

c)

12 wells

d)

16 wells

12.

Part 2 Gel Electrophoresis of Restriction Fragments

Which voltage should we use to run our gel?

a)

75 V

b)

100 V

c)

125 V

d)

150 V

13.

Day 2 Gel Electrophoresis of Restriction Enzymes

In order to make sure you're able to get ALL of your sample out, you should 1st ____ your tubes

a)

freeze

b)

centrifuge (spin)

c)

microwave

14.

Part 2 Gel Electrophoresis of Restriction Enzymes

How much of each sample should you load?

a)

15 microliters

b)

20 microliters

c)

30 microliters

d)

45 microliters