WorksheetsBone Review
Total questions: 10
Worksheet time: 3mins
Which of the following vitamin D preparations would be the most appropriate in a patient with poor renal function?
Calcifediol
Calcitriol
Cholecalciferol
Ergocalciferol
Intermittent administration of PTH produces which of the following?
Impaired Ca2+ absorption in the gut
Inhibition of 1-hydroxylase
Net increase in bone formation
Net increase in bone resorption
A postmenopausal women with a family history of osteoporosis completes a bone mineral density work-up and you find her T-score is –2.6. She tried a short course of teriparitide a year ago but complained of serious depression and mood changes. You elect to try an antibody-based therapy and schedule a time for an injection. Which of the following is the drug you have selected?
Calcitonin
Dihydrotachysterol
Denusomab
Infliximab
Infliximab is effective in RA because it does which of the following?
Binds to TNF-α and sequesters it from receptors
Is a TNF-α receptor agonist
Is a TNF-α receptor antagonist
Is a synovium-specific anti-inflammatory agent
The immunosuppressive effect of methotrexate is a result of its inhibition of which of these?
Dihydrofolate reductase
Leukocyte migration
Microtubule function
Phospholipase A2
A 55-year-old woman is being treated for RA. Her disease has become much worse, and a new medication is added. After 6 months, she notes night sweats, weight loss, chronic cough, and a chest radiograph that indicates a cavitary lesion. Which of the following medications was most likely prescribed for the RA?
Gold salts
Infliximab
Methotrexate
Naprosyn
A 48-year-old man is diagnosed with gout. Allopurinol is useful in treating gout because of which of the following property?
It increases the catabolism of uric acid.
It increases the degradation of uric acid.
It decreases the production of uric acid.
It increases renal excretion of uric acid.
Colchicine is especially useful in treating an acute attack of gout because it achieves which of the following?
Decreases uric acid deposition
Is potent anti-inflammatory agent
Impairs leukocyte migration
Increases the solubility of uric acid
A 44-year-old man is suffering from recurrent gouty arthritis. His serum uric acid level is elevated, and you prescribe allopurinol. Within 1 week of the allopurinol, he develops a painful episode that “feels like gout.” Which of the following is the best explanation?
The patient is resistant to the allopurinol and should be placed on another medication.
The patient likely has an arthritis syndrome produced by allopurinol and should have an antinuclear antibody (ANA) drawn.
The patient likely developed acute gout as a result of mobilization of the urate from joints and tissues.
This likely represents a drug-drug interaction, and so the allopurinol should be discontinued.
A 61-year-old male patient has 5–6 painful gouty attacks every year despite being treated with febuxostat. He is highly allergic to probenecid. Which of the following would be the best course of treatment for this patient?
NSAIDs at maximal doses
Pegloticase
Sulfinpyrazone
Allopurinol
