WorksheetsLecture 2 - Pharma 1
Total questions: 10
Worksheet time: 8mins
Drugs act in the body only through receptors
Yes
No
If 100 molecules of a drug enter the body, and there are 150 receptors for this drug on the cell, in this case max. response
can't occur as the amount of drug is less than no. of receptors
can occur as the 50 extra receptors may be spare receptors
In GPCRs, the magnitude of response towards an agonist can be
equal to the no. of ligand molecules as each one potentiate 1 response
amplified as a cascade or intracellular reactions occur
diminished
An increase in no. of receptors on a cell following repeated exposure to antagonist is known as
Desensitization
Down-regulation
Up-regulation
Supersensitivity
Refractory receptors are
When a time is required by a receptor to re-activate again
The presence of more receptors that can be inactivate however 100% response can be achieved
Coupled with G protein
Tachyphylaxis is
Hypersensitivity of a receptor
Lower sensitivity of a receptor
Decrease in no. of receptors
Same as tolerance
If 1 mg of lorazepam produces the same anxiolytic response as 10 mg of diazepam
Lorazepam is more potent
Lorazepam is more effective
Lorazepam is full agonist, and diazepam is a partial agonist
Lorazepam is a better drug than diazepam
Drug efficacy depends on
Drug intrinsic activity
no. of drug-receptor complexes
no. of bonds between drugs and receptors
If L-dopa antagonizes the effect of dopamine if taken together, then L-dopa is considered as
Full antagonist
Partial antagonist
Full agonist
Partial agonist
Doxazocin can bind to alfa-1 receptor hindering the contraction of endogenous norepinephrine on the bladder as it acts as
Agonist
Partial agonist
Antagonist
Inverse agonist
