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WorksheetsBasic Anesthesia Pharmacology Pre test
Total questions: 10
Worksheet time: 10mins
Which of the following intravenous anesthetics is converted from a water soluble to a lipid-soluble drug after exposure to the bloodstream?
Propofol
Midazolam
Ketamine
None of the above
Correct statement about metabolism of drugs by the liver is .
For drugs with low extraction ratio, liver blood flow is the rate-limiting step in their metabolism
For drugs with high extraction ratio, the capacity of the liver to metabolize the drug is the rate-limiting step
Cytochrome P450 system is highly drug -specific
Removal of the drug from the blood by hepatic clearance is directly proportional to hepatic blood flow and intrinsic clearance
Regarding Meyer–Overton rule:
Potency of inhalational anesthetic agents depends on their lipid solubility.
Only free drug can pass through the cell membrane, be metabolized or excreted.
Fast of onset of inhalational anesthetic agents depends on their lipid solubility.
High vapor pressure of inhalation anesthesia inversely related to their critical temperature.
What is the most accurate statement of the following?
Agonist mean drug that binds to a receptor but not causes a response or effect.
Inverse agonist mean drug that binds to receptor and has an effect opposite to that of an agonist (e.g. flumazenil).
Antagonist mean drug that binds to a receptor and produce a response.
Partial agonist mean Drug that binds to receptor and causes partial response with Intrinsic activity > 1.
Regarding factors affecting drug Bioavailability, which is correct:
small particles and liquid are slow absorbed than enteric-coated preparations.
highly ionized drugs have low bioavailability.
First-pass metabolismin the liver reduces bioavailability.
Route– ketamine has 50% bioavailability orally but 90% IM.
Concerning response to repeated drug doses:
Tachyphylaxis refers to the phenomenon of rapid loss of response to repeated doses of a drug
Tolerance occurs when loss of response occurs over a longer period of administration
Desensitization occurs when incrementally larger doses of drug are required to produce the same response
Desensitization occurs in chronic opiate abuse
The following drug combinations can not potentially cause serious adverse reactions:
Moclobemide and ephedrine
Warfarin and orange juice
Bisoprolol and verapamil
Levodopa and metoclopramide in a patient with Parkinson’s disease
The following drugs not display zero-order kinetics:
Aspirin
Warfarin
Theophylline
Alfentanil
Concerning multi compartmental pharmacokinetic models:
Peripheral compartments represent less vascular structures
A drug can be eliminated from any compartment
Catenary models link a central compartment to peripheral compartments
In three-compartment models, equilibration between central and peripheral compartments occurs at same speeds.
The following drugs cross the placenta in significant quantities:
Co-amoxiclav
Diclofenac
Thiopentone
All of the above
