where the net effect is more than the sum of the individual actions

where one drug increases the effect of another

where the net effect is the sum of the individual actions

Non of mentioned

Isomers are compounds with the same atomic formulae (same molecular weight) but different structural arrangements, and often different properties.

Structural isomers have same chemical structures with the same molecular weight.

Tautomerism is a type of stero isomerism, in which the two isomers exist in equilibrium determined by the surrounding pH.

Stereoisomers have different chemical constituents and structure, but same 3D Spatial configurations.

pK is positive logarithm to base 10 of the dissociation constant for the chemical reaction.

pKa is pH at which 50% of drug is ionized; independent of whether drug is acidic or basic, and depends on molecular structure

Ionized (charged) particles are relatively lipid insoluble and easily cross cell membranes.

Degree of ionization not expressed by Henderson–Hasselbalch equation

For greater safety, a drug should have a low therapeutic index

Warfarin has a high therapeutic index

Penicillin has a low therapeutic index

Ibuprofen has a high therapeutic index

Rifampicin

Amiodarone

Carbamazepine

Chronic alcohol

Aspirin

Warfarin

Theophylline

Alfentanil

It is defined as the time for the plasma concentration of a drug to fall by 50% subsequent

to cessation of an infusion after plasma loading

Remifentanil displays a context-insensitive half-life

Context sensitive half-life predicts time to waking subsequent to termination of infusion of a hypnotic agent

Alfentanil demonstrates context sensitivity after prolonged infusion times

Co-amoxiclav

Diclofenac

Thiopentone

All of the above

Clearance refers to the amount of drug removed from the body per unit time

Elimination of most drugs follows zero-order kinetics

Elimination is always related to renal function

A time constant is longer than a half-life