WorksheetsRECALLS_PHARMA_QUIZ-3
Total questions: 20
Worksheet time: 8mins
Name
Class
Date
1.
A Case of 12-year-old female came in due to febrile episodes with associated headaches and chills. she was diagnosed to have typhoid fever. PMH: (+) G6PD deficiency. Which of the following reason best explain why Chloramphenicol is not indicated with this patient?
a)
It is broad spectrum antibiotics and only reserved for severe infection
b)
It is not a first line treatment of typhoid
c)
It may result to hemolytic type of anemia
d)
All of the above
2.
Which of the following statement is correct?
a)
Drugs exhibit greater protein binding in fetal plasma than in maternal plasma
b)
Antidiabetic drug like glyburide have a significant amount in umbilical and maternal blood
c)
Placenta is also capable of metabolizing some drugs through hydroxylation or demethylation
d)
All of the above
3.
Spectrum of activity of vancomycin EXCEPT
a)
Covers methicillin resistant staphylococcus aureus
b)
Covers methicillin resistant staphylococcus epidermidis
c)
Enterococcal infection other than E. faecium and faecalis
d)
None of the above
4.
Under what FDA drug category is contraindicated in pregnancy?
a)
Category A
b)
Category B
c)
Category C
d)
Category D
5.
Which of the following statement is true in Geriatric population?
a)
Compliance is affected due to underlying co-morbid condition and possibility multiple drug interactions and adverse effects
b)
Decreased production of gastric acid and hence increased absorption of drugs unstable to acid
c)
Usually have physiologic decline in renal, pulmonary and cardiac function
d)
All of the above
6.
Tetracycline has the following characteristics or indication/s
a)
Crosses the placental barrier with insignificant amount on the fetal circulation
b)
Resistance is due to a decrease accumulation as a result of either decreased antibiotic influx or acquisition of an energy dependent efflux pathway
c)
Can be used as monotherapy in the management of H. pylori eradication
d)
Enters the gram (-) bacteria by active diffusion through the hydrophilic channels formed by the porins protein of outer cell membrane
7.
Tigecycline can be used in the management of multidrug resistant organisms as follows EXCEPT
a)
extended spectrum beta lactamase producing Klebsiella pneumoniae
b)
multidrug resistant Acinetobacter baumannii
c)
multidrug resistant Pseudomonas aeruginosa
d)
multidrug resistant staphylococcus aureus
8.
Which of the following is/are indication/s of aminoglycosides?
a)
gram negative aerobic/anaerobic causes infection
b)
used as a regimen in the treatment of 1st and 2nd line anti TB agent
c)
used as a monotherapy in the management of Pseudomonas infection
d)
all of the above
9.
Which of the following is true among macrolides?
a)
either bacteriostatic and bactericidal
b)
all the members are capable of inducing cardiac arrythmia
c)
all the members are prone for drug interactions
d)
devoid of anti TB properties
10.
Which of the following statement is true?
a)
A drug from maternal circulation that enters the fetal liver may be partially metabolized there before entering the fetal circulation
b)
Sulfonamides increases the affinity of B1 to fetal plasma proteins
c)
Drugs are not altered by the hormones secreted during pregnancy
d)
All of the above
11.
True regarding Pharmacokinetics and dynamics of drugs in geriatrics
a)
Drug metabolism are usually affected more especially the phase II reactions
b)
Age related decline in renal function is not reflected in an equivalent rise in serum creatinine
c)
Lower sensitivity to analgesics and hypnotics compared to young adults
d)
All of the above
12.
Drug induced pseudomembranous colitis associated with clostridium dificile
a)
Can be treated with oral clindamycin
b)
Can be treated with oral vancomycin
c)
Can be treated with IV clindamycin
d)
Can be treated with IV vancomycin
13.
Which of the following is incorrect?
a)
Fosfomycin is used in uncomplicated UTI and safe in pregnancy
b)
Mupirocin may cause renal failure if applied on large surface area
c)
Bacitracin is nephrotoxic that’s why is used as a topical agent rather than oral form
d)
None of the above
14.
Increased Sensitivity to analgesic and sedatives are usually seen in
a)
Young adult
b)
Pregnant
c)
Geriatrics
d)
All of the above
15.
Which of the following statement is correct?
a)
Drugs that are secreted in the breast milk is always contraindicated during breast feeding
b)
Resistance at the placenta can be due to efflux mechanism
c)
High molecular weight drugs usually cross the placenta and enter the fetal circulation
d)
All of the above
16.
Which of the following mechanism of resistance of tetracyclines is correct?
a)
Decrease accumulation of tetracycline as a result of either decreased antibiotic influx or acquisition of an energy dependent efflux pathway
b)
Production of ribosomal protection protein displacing tetracycline from its target or mutation
c)
Enzymatic inactivation
d)
All of the above
17.
Which of the following is not correct regarding macrolides?
a)
Have anti TB property
b)
Used as regimen in the treatment of H. pylori eradication
c)
Used for treatment of acne vulgaris
d)
Use in the treatment of atypical causes of pneumonia
18.
Linezolid has the following indications EXCEPT
a)
Multidrug resistant staphylococcus aureus
b)
Can be used in the treatment of TB
c)
Vancomycin resistant enterococcus
d)
Extended spectrum beta-lactamase producing gram negative organism
19.
Aminoglycosides have the following spectrum of activity EXCEPT
a)
Gram positive and gram-negative organisms
b)
Antipseudomonal property
c)
Anti TB property
d)
None of the above
20.
Which of the following drugs have post antibiotic effect?
a)
Azithromycin
b)
Clindamycin
c)
Aminoglycoside
d)
All of the above
100 %
