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WorksheetsCell cycle
Total questions: 18
Worksheet time: 9mins
Which of the following statements is false? Checkpoints of cell-cycle control system ensure that:
the environment is favorable for the cell to initiate DNA replication.
M phase is completed before cytokinesis begins.
all chromosomes are attached to the mitotic spindle before the chromosomes are segregated to the two daughter cells.
all DNA is replicated before M phase begins.
Which of the following statements is false?
Cyclins vary in concentration at different stages of the cycle.
Cyclins help activate Cdks by phosphorylating them.
Cyclins are degraded at specific times in the cycle.
Cyclins have no enzymatic activity on their own.
For a CDK to be active, it must:
bind a cyclin
increase in concentration at a specific time in the cycle
dissociate from its bound cyclin
translocate from the cytoplasm to the nucleus
The cell-cycle control system uses CDK inhibitory proteins:
to stop one phase of the cycle and trigger another
to degrade Cdks
to degrade cyclins
to arrest the cell cycle at specific checkpoints.
In response to DNA damage in a proliferating cell, the p53 protein can arrest the cell cycle or induce the cell to kill itself.
True
False
The five stages of mitosis occur in which order?
Anaphase, prometaphase, metaphase, telophase, prophase
Prophase, metaphase, prometaphase, telophase, anaphase
Telophase, anaphase, prophase, prometaphase, metaphase
Prophase, prometaphase, metaphase, anaphase, telophase
Chromosomes line up the spindle equator during:
Telophase
Metaphase
Prophase
Anaphase
Which of the following statements are true?
Many cells die by necrosis during normal animal development
Many cells die by necrosis in many normal, adult, human tissues
Many cells die by apoptosis in many normal, adult, human tissues
The proteases that dismantle the cell during apoptosis are called:
Lysosines
Condensins
Caspases
Carapases
A cell with shortened telomeres:
Will divide more times than usual
Express high amounts of telomerase
May undergo replicative senescence
Is a tumour cell
Why do telomeres get shorter?
Because there are not enough nucleotides to copy DNA until the end
Because they are stretches of repetitive sequence, which leads to errors in replication of DNA ends
Because they are degraded by the polymerase
Because the ends of the lagging strand cannot be completed once the final primer is removed.
After the DNA damage has been repaired during cell cycle arrest, p53 will be:
degraded
Phosphorylated
Translated
Replicated
The process of "budding" occurs during which method of cell death?
Apoptosis
Necrosis
Senecence
Caspases are proteases which are responsible for apoptosis, which themselves are regulated by Bcl2 proteins, which are:
Pro-apoptotic
Anti-apoptotic
Both pro and anti-apoptotic
DNA replication occurs:
S phase in Interphase
S phase in M phase
G1 phase in Interpase
G2-M phase in M phase
I
Primase synthesis what during DNA replication
Synthesizes DNA using RNA as a template
Synthesies cDNA from DNA
Synthesises RNA using DNA as a template
DNA brakes
DNA torsional stress, caused by replication is corrected by:
DNA helicase
DNA primase
Topoisomerase
Okazaki fragments
Which two processes together constitute the M phase of the cell cycle?
Interphase and mitosis
Mitosis and cytokinesis
Interphase and metaphase
S phase and G1
