WorksheetsPC HF part 2
Total questions: 21
Worksheet time: 11mins
How does a NEP inhibitor lower BP?
increases the level of vasodilator peptides
decreases the level of vasoactive peptides
decreases level elf vasoconstrictor peptides
increases the level of vasoconstrictor peptides
Which of the following inhibitors increases the level of vasoactive peptides?
renin inhibitors
PDE inhibitors
NEP inhibitors
ACE inhibitors
NEP causes
vasodilation in all vessels
vasoconstriction in all vessels
effect largely depends on whether the predominant substrate degraded by NEP is a vasodilator or vasoconstrictor
In vasoconstriction, NEP is involved in the enzymatic conversion of Big ET-1 to its active form. What is the active form?
ET-1
BNP
ANP
ANG-11
Which of the following reduces the risk of CV death and HF hospitalization?
sacubitril/valsartan
sildenafil
lithium
spironolactone
The film coated tablet of Entresto are unstable in which pH?
alkaline
neutral
acidic
none of the above
Which of the following is FALSE regarding Entresto?
no starting dose adjustment is needed for mild or moderate renal impairment
can be taken with or without food
not recommended in severe renal impairment
does not cross the BBB
If a patient has severe renal impairment and is starting Entresto, what must be done?
starting dose adjustment is necessary
no starting dose adjustment is required
not recommended in severe renal impairment
recommend a different drug
Sacubitril is a prodrug that is activated to Sacubitrilat (LBQ657) by __________ via _________.
demethylation; esterases
de-ethylation; esterases
hydrolysis; amidase
decarboxylation; hydrolysis
What are the 2 mechanisms of action for Entresto (Sacubitril/Valsartan)?
inhibits angiotensin converting enzyme
inhibits Na/K ATPase
inhibits neprilysin
blocks the AT1 receptor
Although the clinical relevance is unknown, which drug increases the levels of amyloid-B1 in the cerebrospinal fluid?
Entresto
Ivabradine
omaprartilat
carvedilol
Sacubitril/Valsartan (Entresto) may result in what adverse event(s)?
angoiedema
hypotension
impaired renal function
all of these
Which drug(s) should NOT be taken with Entresto?
ACEIs
NSAIDs
COX-2 Inhibitors
all of these
Which of the following drugs interacts with spironolactone?
sodium supplement
potassium supplement
magnesium supplements
Next generation ARBs will inhibit _________ using bifunctional single compounds that reduces the adverse effects associated with combination therapy.
neprilysin activity
AT1 receptor response
AT2 receptor response
the renin-angiotensin system
Ivabradine inhibits...
hyperpolarization-activated cyclic nucleotide gated (HCN) channels
NEP
renin
angiotensin II
Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that does what to the spontaneous pacemaker activity of the cardiac sinus node?
increases
nothing
reduces
Which of the following is an adverse reaction of Ivabradine?
conduction disturbances
luminous phenomena (phosphenes)
suicidal ideation
tachycardia
Which of the following is true regarding Ivabradine?
use can cause ventricular fibrillation
safe to use while breastfeeding
ivabradine is safe in pregnancy
use can cause heart block
Which of the following is NOT an adverse reaction of ivabradine?
fetal toxicity
atrial fibrillation
hepatotoxicity
bradycardia
All are adverse reactions to Entresto, except:
angioedema
hypoglycemia
hypotension
hyperkalemia
