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Worksheetspre test opioid pharmacology
Total questions: 10
Worksheet time: 8mins
Opioid analgesics cause all of the following effects except
Contraction of smooth muscle of the gallbladder
Contraction of detrusor muscle of the urinary bladder
Depress cellular immunity
Delayed gastric emptying
Which of the following are natural opiates?
Codeine
Oxycodone
Fentanyl
Endomorphins
Which of the following are semi-synthetic opiates?
Codeine
Oxycodone
Fentanyl
Endomorphins
What is opiophobia?
Fear of opioid plant
Fear of drugs
Fear of prescribing opioid drugs
Fear of anesthesia
A 55-year-old man complained of severe pain after surgery to remove a colon cancer. The physician ordered a drug that is a partial mu opioid agonist, more potent than morphine and whose effects are not readily antagonized by naloxone. Which of the following drugs was most likely administered?
Methadone
Meperidine
Buprenorphine
Fentanyl
Which of the following is TRUE regarding context-sensitive half-time ( CSt½ ) for opioids
It is the time needed for a drug's steady-state plasma concentration to decrease to one-third upon stopping its continuous infusion.
For fentanyl the CSt½ is independent of the duration of the infusion
The extremely short CSt½ of remifentanil is due to its rapid clearance from the plasma.
The time to the loss of analgesia after an opioid infusion is solely dependent on the CSt½.
Which physical characteristic of fentanyl best accounts for its rapid onset of clinical effect as well as its brief duration of
action?
High lipid solubility
High degree of ionization
Relatively small molecular weight
Low hepatic clearance
The clinical effects of meperidine that differ from those observed with other commonly used opioids include:
Absence of histamine release from tissue mast cells
Increase in cardiac index after high doses
Less nausea and vomiting at equianalgesic doses
Direct local anesthetic effects
181. Which of the following opioid-receptor agonists has anticholinergic
properties ?
Morphine
Hydromorphone
Sufentanil
Meperidine
Compared with sufentanil, alfentanil is characteriz ed by
Higher pKa
Larger unionized fraction at physiologic pH
Less protein-binding
Greater lipid solubility
