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WorksheetsMetabolism of special lipids
Total questions: 20
Worksheet time: 15mins
Which of the following are not true about lipid rafts?
Has cholesterol and sphingomyelin
found in the outer leaflet of the plasma membrane
Functions in membrane signaling and trafficking
can't have protein
Under glycerophospholipids, which of the polar head groups are not included?
Serine
Inositol
Ether
Choline
In the synthesis of glycerophospholipids, what does Cytidine triphosphate do?
Activates a headgroup by phosphorylation
Releases Cytidine monophosphate
Dephosphorylates phosphatidic acid to 1,2-diacylglycerol
There are two pathways in glycerophospholipid synthesis. Find the odd one out.
Phosphatidylserine
Phosphatidylinositol
Phosphatidylethanolamine
Phosphatidylcholine
Which of the following statements are false regarding the synthesis of ether glycerolipids?
precursor is dihydroxyacetone
Forms 1-alkyl glycerol-3-phosphate
Biosynthesis is located in the mitochondria
Involves the enzyme 1-alkylDHAP reductase
A baby was found to have Rhizomelic shortening of their long bones, joint contractures, nasal hypoplasia and Ichthyosis. The doctor diagnosed him with Rhizomeric chondrodysplasia punctata. What caused this?
Ethanolamine in plasmalogen synthesis
Impairment in plasmalogen biosynthesis
Presence of an enzyme that desaturates the alkyl chain
The oxidation of NADH to NAD+
Which of the following phospholipases is matched correctly with their function?
Phospholipase A1 - Acts on Sn3 position
Phospholipase C - Acts on Sn2 position
Phospholipase B - Acts on Sn1 position
Phospholipase D - Acts on Sn2 position
Which of the following main classifications of lipids functions as the antigenic determinants of ABO blood groups?
Glycerolipids
Sphingolipids
Phospholipids
None of the above
Which of the following glycolipids does not contain galactose?
Galactocerebroside
Sulfatide
Glucocerebroside
Globoside
What disease results from the accumulation of glucocerebroside and the deficiency in beta-Glucosidase?
Fabry's Disease
Nielmann-Pick Disease
Tay-Sachs Disease
Gaucher's Disease
Sphingolipidoses has an enzymatic defect in the lysosomal degradation pathway of sphingolipids. What is not a treatment for sphingolipidoses?
Hormone rehabilitation
Gene therapy
Bone Marrow transplantation
Enzyme replacement therapy
What is a not a function of Eicosanoids?
Regulate smooth muscle contraction
Serve as modulators
Increase water and sodium excretion by the kidney
Produce bile salts
In the liberation of arachdonic acid, there are 2 pathways. Which of the following statements are correct?
Phospholipase A2 pathway is longer than the Phospholipase C pathway
Phospholipase A2 pathway is shorter than the Phospholipase C pathway
Phospholipase A2 pathway is just as long as the Phospholipase C pathway
None of the above
In the synthesis of Eicosanoids, there are 3 major pathways for the metabolism of arachidonic acid. Which pathway would give me diHETE?
Cyclooxygenase pathway
Lipoxygenase pathway
Cytochrome P450 pathway
In the biosynthesis of sphingosine, which is one of the main substrates?
Phosphatidylcholine
Palmitoyl-CoA
Phosphatidic acid
Glycerol
What is the mechanism of action of steroidal anti-inflammatory agents?
irreversibly blocking cyclooxygenase
promoting the release of arachidonic acid
blocking phospholipase A2
converts PGH2 to PGE2
In the biosynthesis of glycolipids, which of the following functions as the NANA carrier?
CMP
UDP
AMP
ATP
Which of the following is true?
Sphingosine backbone + fatty acid + carbohydrate = sphingomyelin
Sphingosine backbone + fatty acid + choline = glycolipid
All of the above
None of the above
To form phosphatidylinositol, what does inositol displace?
CDP-DAG's phosphate group
Phosphatidic Acid's hydroxyl group
CMP's methyl group
None of the above
Based in the lipoxygenase pathway, which are correctly paired?
5-lipoxygenase : platelets
12-lipoxygenase : polymorphonuclear leukocytes
15-lipoxygenase : eosinophilic leukocytes
2-lipoxygenase : macrophages
