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Fuchs Endothelial Corneal Dystrophy

Total questions: 10

Worksheet time: 5mins

Name
Class
Date
1.

Which of the following acts against normal corneal deturgescence?

a)

Endothelial pump function

b)

Endothelial barrier function

c)

Stromal imbibition pressure

d)

Epithelial barrier function

2.

Which of the following subtypes of Fuchs Endothelial Corneal Dystrophy comes under Category 1 of IC3D classification?

a)

Early onset FECD

b)

FECD 3

c)

FECD 7

d)

FECD 4

3.

Mutation in which of the following ion transporters in associated with both Fuchs Endothelial Corneal Dystrophy as well as Congenital Hereditary Endothelial dystrophy?

a)

Na+-K+ ATPase

b)

SLCA411

c)

pNBCe1

d)

NHE1

4.

Mutation in which gene has been associated with early onset Fuchs Endothelial Corneal Dystrophy?

a)

SLCA411

b)

LOXHD1

c)

COL8A2

d)

ZEB1

5.

Which component of extra-cellular matrix is not found in normal corneas but present in Fuchs Endothelial Corneal Dystrophy?

a)

Laminin

b)

Fibronectin

c)

Oxylatan

d)

Perlecan

6.

What is the clinical hallmark of Fuchs Endothelial Corneal Dystrophy?

a)

Endothelial Polymorphism

b)

Endothelial Polymegethism

c)

Endothelial Guttae

d)

Microcystic Corneal edema

7.

Burried guttae generally lie between which two layers of the Descemet's membrane?

a)

Anterior banded layer and Posterior non-banded layer

b)

Posterior non-banded layer and posterior banded layer

c)

Stroma and anterior banded layer

d)

Posterior banded layer and posterior fibrillar layer

8.

In which clinical stage of FECD does the patient complain of episodes of pain?

a)

Stage 1

b)

Stage 2

c)

Stage 3

d)

Stage 4

9.

Which of the following modalities cannot image the endothelium in presence of corneal opacity or edema?

a)

In vivo Confocal microscopy

b)

Specular microscopy

c)

Confocal microscopy

d)

All can image

10.

In which of the following clinical scenarios should a triple procedure be performed?

a)

Symptoms of morning blur with early cataract

b)

Clear cornea with central guttae and visually significant cataract

c)

Central corneal thickness > 600 microns, endothelial cell count > 2000cells/sq.mm, clear cornea, visually significant cataract

d)

All the above