WorksheetsGrihadeep Paul_MPT1062_03
Total questions: 20
Worksheet time: 10mins
A dosage form which delivers drugs at a predetermined rate for a specific period of time
Controlled dosage form
Transdermal dosage form
Targeted dosage form
Conventional dosage form
Timed release drug delivery system are used to obtain the drug release after a lag time of about
3 to 4 hours
4 to 5 hours
2 to 3 hours
more than 5 hours
For successful development of drug delivery system, which of the following basic
understanding is necessary?
Pharmacodynamic & Pharmacokinetic
profile of a drug
Physicochemical characteristics of a drug
Anatomy & Physiology of GIT
All of these
The full form of MEC is
Maximum effective concentration
Minimum effective concentration
Maximum effective conductivity
Minimum effective conductivity
The full form of MSC is
Maximum stability concentration
Minimum stability concentration
Maximum safe concentration
Minimum safe concentration
A good candidate for controlled drug delivery should have half life of
2 - 4 hr
Less than 1 hr
8 - 10 hr
More than 4 hr
In case of SRDDS, the pKa range for acidic drug whose ionization is pH sensitive is around
4 to 6
3 to 7.5
3 to 4
5 to 7
The curve between log drug activity & log K, is structurally
Helical bell shaped
Straight line passes through origin
Bell shaped
Straight light that does not pass through origin
The rate limiting step for the controlled release dosage form
Dissolution
Drug release from dosage form
Drug absorption
Drug penetrate
For the selection of SRDDS, the physicochemical factors are
Drug stability & Diffusivity
Molecular size
Protein Binding
All of the above
For selection of oral SRDDS, the release should not be influenced by
Solubility
pH & enzymes
pH
Enzymes
The drug release from oral controlled release dosage form follows
Zero order kinetics
First order kinetics
Pseudo first order
Second order kinetics
The following Characteristics are the good candidates for Controlled release dosage form
Polar, ionized
Polar, non-ionized
Non-polar, unionized
All of the above
Partition coefficient is represented by....
P(o/w)
P(w/o)
P(w/o/w)
P(o/w/o)
To eliminate the drug substance from the blood circulation quickly the half life of that substance should be
Larger
Medium
Shorter
Half life can not be a factor
A three phased emulsions with partitions and for sustained release are
Multiple emulsion
Micro emulsion
Triphasic emulsion
Emulsion
Challenges to sustained release drug delivery are.....
Fate of the controlled release system
Cost of the formulation
Biocompatibility
All of these
Specifically enteric coated tablet is....
Controlled release dosage form
Extended release dosage form
Delayed release dosage form
Sustained release dosage form
Industrial advantages of the CRDDS are
Patent extension
Product life cycle extension
Market expansion
All of the above
Slow dissolving salt of penicillin G which is formulated a sustained dosage form
Benzyl penicillin
Procaine penicillin G
Both A & B
Benzathine Penicillin G
