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Genetics of Cancer

Total questions: 21

Worksheet time: 11mins

Name
Class
Date
1.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

inhibits cell division

a)

proto-oncogenes

b)

tumor suppressor genes

2.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

stimulates cell division

a)

proto-oncogenes

b)

tumor suppressor genes

3.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

requires mutation in both alleles to cause cancer.

a)

proto-oncogenes

b)

tumor suppressor genes

4.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

requires mutation in only one allele to cause cancer

a)

proto-oncogenes

b)

tumor suppressor genes

5.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

mutation in allele is a dominant trait

a)

proto-oncogenes

b)

tumor suppressor genes

6.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

mutation in allele is a recessive trait

a)

proto-oncogenes

b)

tumor suppressor genes

7.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

functions like a gas pedal in car

a)

proto-oncogenes

b)

tumor suppressor genes

8.

Decide if the following description matches a proto-oncogenes or tumor suppressor genes.

functions like a brake pedal in car

a)

proto-oncogenes

b)

tumor suppressor genes

9.

Cancer is

a)

hyperactive metabolism

b)

uncontrolled cell division

c)

uncontrolled cell death

d)

specialization of cells for a particular job

10.

This term means "programmed cell death". It is when a cell is "told" to die, rather than death by disease or wearing out.

a)

senescence

b)

apoptosis

c)

planned obsolescence

d)

die, just die, darn you liver cell!

11.

This is a gene that could cause cancer, but needs some sort of alteration or mutation to do so.

a)

oncogene

b)

proto-oncogene

c)

tumor suppressor gene

d)

Gene Kelly

12.

A gene that protects a cell from becoming cancerous.

a)

oncogene

b)

proto-oncogene

c)

tumor suppressor gene

d)

apoptosis

13.

Which of these is NOT a sign of cancer cells?

a)

Consistent and widespread apoptosis

b)

Loss of specialized features such as large fat bodies

c)

Variety of sizes and shapes in the same cell types

d)

Larger nucleus, smaller amount of cytoplasm

14.

What features would you look for in a cancer cell?

a)

Larger or irregularly shaped nucleus

b)

Loss of features such as flat, square shapes and protrusions that the cell type should have

c)

Lack of well-arranged cells; positions are random with a variety of sizes

d)

All of these are indications of cancer

15.

Programmed cell death is known as

a)

metastasis

b)

angiogenesis

c)

malignant

d)

apoptosis

16.

Recruitment of blood vessel by a tumor is referred to as

a)

metastasis

b)

apoptosis

c)

angiogenesis

d)

benigh

17.

Process by which cancer cells have migrated to another location in the body is called

a)

apoptosis

b)

malignant

c)

genetic flow

d)

metastasis

18.

Which of the following is NOT a way in which a proto-oncogene can be converted into an oncogene?

a)

mutation that results in a degradation-resistant protein

b)

translocation of a proto-oncogene to a more active promotor region.

c)

duplication of gene within the genome.

d)

mutation that results in a protein that has lost its function

19.

Cancer in supporting tissue such as bone or muscle is referred to as

a)

carcinoma

b)

sarcoma

c)

lymphoma

d)

leukemia

20.

Cancer of the blood due to cells in bone marrow divided out of control is referred to as

a)

carcinoma

b)

sarcoma

c)

lymphoma

d)

leukemia

21.

In normal tissue, the

a)

rate of mitosis is equal to the rate of apoptosis

b)

rate of mitosis is much greater than the rate of apoptosis

c)

rate of mitosis is less than the rate of apoptosis

d)

rate of mitosis and apoptosis will be zero