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WorksheetsAnimal Model_Reporting
Total questions: 25
Worksheet time: 26mins
What factors gives impact to the obesity and pathophysiology on developing several metabolic derangements?
Obesity
Mg deficiency
Stress
Aging
Gender
What type of mice is used which developed severe obesity, promoted differential WAT distribution which is in correlation with increased adipocyte size?
CHOW fed female young mice
CHOW fed female aged mice
HFD fed young female mice
HFD fed female aged mice
Which type of mice is most commonly used inbred strain in research and laboratory because of their genetically identical colonies within each strain?
C56 black 6 mice or ”B6 mice”
129-Elite (SOPF) mice
C57 black 6 mice or ”B6 mice”
BALB/c mice
Under what phylum is Caenorhabditis elegans classified?
Mollusca
Annelida
Porifera
Nematoda
Which of the following is not a characteristic of Caenorhabditis elegans?
Unicellular
Transparent
Short Lifespan
Hermaphroditism
(Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans) Which compound was used for fuorescence quantification?
Sodium azide
Sodium amide
Nitrous oxide
Liquid ammonia
What type of diabetes occurs due to insulin resistance or insensitivity of cells of the body to the presence of insulin?
Type 2
Type 1
Gestational
Type 3
Preeminent biologist that used Drosophila melanogaster for experiments
Thomas J. Baranski
Antonie Van Leeuwenhoek
Thomas Hunt Morgan
Rolf Bodmer
This is an essential hormone produced by the pancreas. Its main role is to stop blood sugar levels from rising too high
flavonoid
alkaloid
beta cells
Insulin
At what stage does the third and final instar of Drosophila melanogaster occur?
Day 12
Day 7
Day 5
Day 3
How many eggs can a Denio rerio can produce in each mate?
200
100
50
400
____% of diabetes cases are type II
90
75
50
68
What specific reactive carbonyl species (RCS) can be detoxified by glyoxalase 1?
glucagon
ALDH
Methylglyoxal
4-hydroxynonenal
Which rat is used in studying the effects of Diane-35 for PCOS?
Hanover Rat
Sprague Dawley Rat
Big Red Wharf Rat
Norwegian Rat
PCOS stands for?
Polycystic ovary system
Polycystic ovulation syndrome
Polyclonal ovary syndrome
Polycystic ovary syndrome
Diane-35 in combination with metformin can improve ovarian energy metabolism by?
lowering the temperature by 2 degrees celsius
increasing ADP and glucose molecules
regulating the glycolysis pathway
regulating the gluconeogenesis pathway
Majority of the Bifidobacterium bifidum can be found in all of the following EXCEPT
lower small intestine
colon
breast milk
esophagus
Bifidobacterium bifidum is a ____?
gram-positive anaerobic bacterium
gram-negative anaerobic bacterium
gram-negative aerobic bacterium
gram-positive aerobic bacterium
In the study regarding pro-inflammatory milieu triggered by large intestinal microbiota, which cytokine is considered to regulate intestinal inflammation?
INF-γ
TNF-α
IL-1
IL-10
What animal model was presented?
Mice
Rabbit
None of the Above
Human Cell Line
This enzyme promotes the production of prostaglandins (PGs) and induces inflammation and proliferation.
Transglutaminase
Acetylcholinesterase
DNA polymerase
Cyclooxygenase-2
A process involving freezing cell lines to reduce risk of microbial contamination
Sterilization
cryopreservation
Blast Freezing
Suspended animation
What is the animal model that distinctly illustrates cholesterol metabolism in humans?
JW rabbits
PHT rabbits
WHHL-TGH rabbits
WHHL rabbits
What is the method used to test the ability of the rabbits to secrete beta-cells?
Oral Glycogen Tolerance Test
Non-esterified Fatty Acid Assay
Oral Glucose Tolerance Test
Intravenous Glucose Tolerance test
Based on the NAS in rabbits, the percent of infarct volume (%IV) ____ as the number of major cerebral vessel occlusions increases. The increase in vessel occlusions _____ the effective collateral blood flow in the penumbra.
increases, increases
decreases, decreases
decreases, increases
increases, decreases
