WorksheetsPractice questions
Total questions: 10
Worksheet time: 8mins
Prostacyclin (PGI2):
(Choose 2)
A. Is synthesised by mast cells
B. Mediates vasoconstriction
C. Inhibits platelet aggregation
D. Production is inhibited by aspirin
Cytokines
Mostly act locally on the cells that produce them, and rarely at distant sites
Have individual actions in modulating cell function, that are specific to each cytokine
Bind to non-specific receptors on target cells
Are involved in stimulating cell growth, but not cell differentiation
Effects of complement activation may include
A. Opsonisation
B. Lysis of bacteria
C. Chemotaxis of neutrophils
D. Haemolysis
Mechanisms of adhesions between leukocytes and endothelial cells include (choose 3)
A. Increased binding activity of integrins
B. L-selectin/ICAM-1 interaction in low-flow conditions
C. Induction of endothelial adhesion molecules
D. Redistribution of P-selectin by histamine stimulation
During the early stages of the inflammatory response, histamine-induced increased vascular permeability is most likely to occur in
Pre-capillary arterioles
Capillaries
Post-capillary venules
Veins
Chemotaxis is
Fusion of phagosomes to lysosomes
Attachment of mediators to extracellular material to increase phagocytosis
Movement of cells toward a certain stimulus
Transmigration of cells from blood vessels into tissue
A 5 year old child with recurrent bacterial infections, has analysis of peripheral leukocytes showing deficiency in myeloperoxidase (MPO). A reduction in which process is the most likely cause for the increased susceptibility to infections
Nitric oxide (NO) production
Lysosyme production
Hypochlorite (H2O2) formation
Prostaglandin production
A 65 year old woman takes ibuprofen for osteoarthritis, her pain is alleviated by reduced synthesis of the following mediators (choose 2)
Thromboxane A2 (TXA2)
Histamine
Leukotriene E4 (LTE4)
Prostaglandins
This mediator, produced by the action of lipoxygenase on arachidonic acid metabolites, is a potent chemotactic agent for neutrophils
Prostacyclin (PGI2)
IL-8
Thromboxane A2 (TXA2)
Leukotriene B4 (LTB4)
During acute inflammation, increased vascular permeability is induced by multiple mediators, including histamine released from
Neutrophils
Mast cells
Macrophages
T lymphcoytes
