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WorksheetsChapter 141: Adamantiades-Behçet Disease
Total questions: 10
Worksheet time: 10mins
SELECT ALL infectious agents that are implicated in initiating disease onset in Behçet disease
HSV-1
HSV-2
Streptococcus sanguis
Mycoplasma fermentans
Staphylococcus aureus
All of the following are TRUE regarding the pathophysiology of Behçet disease, EXCEPT FOR:
It is a Th1-mediated inflammatory disease
It is a disease of defective T-cell immunity, with no B-cell impairment
Th17 and the IL17/IL23 pathway may play an important role
Tropomyosins and Kinectin are autoantigens of the disease
Which cytokine plays a major role in Behçet disease and is a sensitive marker for disease activity?
IL-1
IL-8
IL-12
IL-17
IL-23
All of the following describe genital ulcers in Behçet disease, EXCEPT FOR:
They are the presenting sign in more than 80% of cases
They often heal with a characteristic scar
Genital ulcers are more persistent than oral aphthae
They can occur on the penis, scrotum, vagina, labia, and urethra
What is the most diagnostically relevant ocular lesion in Behçet disease?
Retinal vasculitis
Anterior uveitis
Hypopyon
Cataract
Glaucoma
All of the following are TRUE regarding systemic involvement of Behçet disease, EXCEPT FOR:
Symmetric, polyarticular arthritis is a common manifestation
Arterial involvement usually presents in the form of aneurysms
Pulmonary artery aneurysms are the principal feature of pulmonary involvement
Sterile prostatis and epididymitis may be seen in male patients, even without genital ulcers
Neurologic manifestations usually present with a severe headache
All can be considered as manifestations of the pathergy phenomenon, EXCEPT FOR:
A 3mm erythematous macule on the volar forearm after a skin needle prick with a 20-gauge needle
Oral aphthae after injury
Aneurysms around vascular anastomoses
A pustule on the volar forearm after intracutaneous injection of 0.1mL isotonic saline
Recurrence of ulcers after resection of affected bowel segments
A 25-year old male patient was referred to you by the Psychiatry service. He presented with recurrent oral ulcers and follicular pustules over his extremities. He also complained of severe headaches and insomnia. You performed a pathergy test and it came out negative. TRUE OR FALSE: The patient fulfills the International Criteria for Behçet Disease.
TRUE
FALSE
SELECT ALL markers for severe prognosis in Behçet disease.
HLA-B51 positivity
Male gender
Female gender
Early development of systemic signs
Recurrent erythema nodosum
A 16-year old male patient with recurrent aphthous and genital ulcers, progressive blurring of vision, large skin ulcers with violaceous, undermined borders, and joint pain of his bilateral knees and ankles. You diagnosed him as a case of Behçet disease. All of the following are TRUE regarding the diagnosis and management of his condition, EXCEPT FOR:
A positive pathergy test is required to fulfill the international criteria for diagnosis
Systemic treatment is warranted for this case because of its poor prognosis
Oral and intravenous prednisolone combined with cyclosporine A have a synergistic effect for ocular involvement
Rapid relapse can occur after discontinuation of systemic treatment
