WorksheetsISBP 2B Dna synthesis and integrity
Total questions: 19
Worksheet time: 11mins
folic acid also know
vitamin B 9
vitamin B 12
vitamin B 6
vitamin B 1
folic acid roles:
heart repair
DNA, RNA creation and repair
stomach repair
brain function
folic acid pathway
THF serve as a cofactor in only one reactions involve in DNA, RNA, protein synthesis
THF serve as a cofactor in many reactions involve in DNA, RNA, protein synthesis
match the competitive inhibitor
diahydropteroate synthase
Sulfonamides
Trimethoprim
match the competitive inhibitor
dihydrofolate reductase (DHFR)
Sulfonamides
Trimethoprim
are Sulfonamides bactericidal or bacteriostatic?
bactericidal
bacteriostatic
Sulfonamides resdistance is fairy common
no
yes
Sulfonamides
Most gram-negatives but NOT PSA (except sulfadiazine)
yes
no
Sulfonamides
High rate of E. coli resistance
yes
no
Sulfonamides
Nocardia, legionella, Pneumocystis jiroveci (formerly carinii)
yes
no
Sulfonamides
mycoplasma coverage
yes
no
Sulfonamides
B. fragilis (or other anaerobes)
yes
no
Sulfonamides
adverse effects
GI distress
Photosensitivity
headache
Nephrotoxicity (crystalluria)
Sulfonamides
adverse effects
hypersensitivity (including SJS)
Hemolytic anemia
rash
photosensitivity
Sulfonamides
avoid in pregnant patients
yes
no
DHFR inhibitors
resistance can be due to
DHFR overexpression
decrease affinity to enzyme
increase affinity to enzyme
decrease cell permeability
DHFR inhibitors
very selective
trimethoprim
bacterial
protozoal
DHFR inhibitors
very selective
pyrimethamine
bacterial
protozoal
DHFR inhibitors
trimethoprim
adverse effects
Hyperkalemia,
amiocentesis
hematologic (rare)
photosensitivity
