WorksheetsAntimicrobials
Total questions: 23
Worksheet time: 25mins
An antimicrobial drug which has a broad spectrum of activity:
is usually bacteriostatic
is active against a number of different bacteria
is active against all types of microorganisms
is always bactericidal
is active against only a few types of bacteria
Antibacterial compounds that affect cell wall synthesis:
are usually bactericidal and have low toxicity to humans
usually induce allergic reactions
all belong to the penicillin group of antibiotics
only affect Gram-positive organisms
interfere with phospholipid synthesis
T or F. Antibiotics that target protein synthesis have selective toxicity because eukaryotic microorganisms do not have ribosomes
true
false
T or F. Beta-lactamase is ineffective against glycopeptide antibiotics
true
false
Development of resistance to antibacterial drugs:
occurs only in people who take a lot of antibiotics
only occurs in bacteria which have been exposed to antimicrobial drugs
is accompanied by a change in the composition of the DNA of the bacteria
only occurs in nosocomial (hospital) organisms
can only be acquired from other bacterial species
Which term is used to describe a drug which kills bacteria or other pathogenic agents without causing damage to the host cell?
synthetic antimicrobial
an antibiotic
selectively toxic
bactericidal
bacteriostatic
Quinolones inhibit which bacterial enzyme?
DNA polymerase
DNA gyrase
nucleotide reductase
ligase
topoisomerase I
Which of the following antibiotics does not affect cell wall synthesis?
penicillin
vancomycin
carbapenem
gentamicin
cephalosporin
Which of the following antibiotics inhibits folic acid synthesis?
tetracycline
neomycin
chloramphenicol
ampicillin
sulfanilamide
Which of the following is not a mechanism used by bacteria to develop resistance to antibacterial drugs?
alteration of membrane permeability
alteration of ribosomal size
alteration of binding sites
mutation
production of enzymes
Define bacteriolytic
inhibits growth of bacteria
bacteria are killed
bacteria killed by lysing cells
T or F. Superinfection is acquired during antimicrobial treatment
true
false
What are the sources of antimicrobial agents?
natural
semisynthetic
synthetic
acquired
Antimicrobials can be classified by:
1. molecular structure
2. mode of action
3. spectrum of activity
1,2 & 3
1 & 3 only
3 only
2 only
1 & 2 only
Which of the following are beta-lactum antibodies?
penicillins
carbapenems
cephalosporins
monobactams
aminoglycosides
What do beta-lactum antibodies do?
1. prevent peptidoglycan cross-linking
2. block transpeptidases
3. disrupts the integrity of phospholipid bilayer
1 & 2 only
1, 2 & 3
1 only
3 only
2 & 3 only
T or F. Beta-lactamases can inactivate beta-lactam antibodies
(a)
Which of the following antibiotics is more resistant to beta-lactamases
cephalosporins
monobactams
carbapenems
penicillin
T or F. Aminoglycosides are antibodies that contain amino salts bonded by glycosidic linkage
(a)
What is the mode of action steps?
cell wall synthesis, protein synthesis,
nucleic acid replication, injury to plasma membrane, metabolite synthesis
protein synthesis, nucleic acid replication, cell wall synthesis, metabolite synthesis, injury to plasma membrane
metabolite synthesis, injury to plasma membrane, nucleic acid replication, protein synthesis, cell wall synthesis
Which of the following antibiotics inhibits DNA gyrase?
quinolones
rifamycin
tetracyclines
marolides
What is the correct order of resistance?
blocking entry, inactivating enzyme, alteration of target molecule, efflux of antibiotic
efflux of antibiotic, alteration of target molecule, inactivating enzyme, blocking entry
alteration of target molecule, blocking entry, efflux of antibiotic, inactivating enzyme
T or F. Antimicrobials can kill microorganisms that are part of the normal microbiota
(a)
