WorksheetsChapter 149 Wound Healing
Total questions: 13
Worksheet time: 13mins
All of the following are TRUE about the coagulation cascade, EXCEPT FOR:
Platelets are the main cell type involved
Hageman factor XII initiates the intrinsic coagulation cascade
Tissue factor initiates the intrinsic coagulation cascade
Serotonin facilitates cell migration by increased vascular permeability
All the following are TRUE regarding inflammation in wound healing, EXCEPT FOR:
Neutrophil infiltration of the wound site occurs at 24 to 48 hours
Macrophages appear in the wound site at 72 hours
Neutrophils are the main phagocytic cells
Activation of growth factors requires a hypoxic and acidic wound environment
All of the following apply to M1 macrophages, EXCEPT FOR:
Activated by IL-4, IL-13
Releases IL-12
Promotes a proinflammatory Th-1 response
Classically activated macrophages
Delayed healing may result from all of the following, EXCEPT FOR:
Inappropriate levels of inflammation
Presence of biofilms
Moist wound environment during the acute wound phase
C-myc expression on keratinocytes found at wound edges
All of the following are TRUE regarding proliferation, EXCEPT FOR:
PDGF and TGF-B attract fibroblasts to the wound bed and stimulate collagen production
MMP allows re-epithelialization by facilitating detachment of keratinocytes from the wound edge
Connective tissue in the healing wound are formed by collagens I, III, IV, and V
Moist wound environments facilitate the process of epithelialization
All of the following are TRUE regarding the remodeling phase, EXCEPT FOR:
A phenotypic switch occurs and fibroblasts become myofibroblasts
ECM material is altered, where collagen type I becomes collagen type III
Tensile strength increases to a maximum of 80% of non-injured skin
Contraction is responsible for 40% of the decrease in wound size
Repair starts to replace regeneration during what stage of embryogenesis:
First trimester
Second trimester
Third trimester
After childbirth
Which of the following growth factors is FDA approved for wound healing?
PDGF-BB
bFGF
GM-CSF
TGF-B
Identify: Recombinant human PDGF-BB that is the only FDA-approved drug for non-healing neuropathic diabetic foot ulcers.
(a)
All of the following cytokines/growth factors are correctly paired with their corresponding function, EXCEPT FOR:
PDGF: cytokine with the highest angiogenic activity
TGF-B: over-expression leads to hypertrophic scar and keloid formation
GM-CSF: promotes proliferation of neutrophils
VEGF: parallels hypoxic gradient and stimulates angiogenesis
All the following antiseptics are correctly paired with their main disadvantages, EXCEPT FOR:
Povidone-iodine: toxic to granulation tissue
Chlorhexidine: damages cartilage/ear toxicity
Silver sulfadiazine: promotes fungal growth
Honey alginate: botulism
You're treating a patient with a non-healing ulcer. You noted painful erythema of the wound edges and purulent discharge. You request for cultures, which showed growth of MRSA. Which of the following wound dressings should you avoid?
Hydrogels
Hydrocolloids
Foams
Collagen-based dressings
You are managing a patient with tender, shallow red-based ulcers with no purulent discharge on her bilateral lower legs. She also presented with increased varicosities and long-standing eczematous changes of the surrounding skin. On follow-up, she developed acute, painful, bright red erythema of both legs with no associated systemic symptoms. You took tissue biopsies and cultures and gave an empiric course of oral antibiotics. Tissue biopsy showed nodular angioplasia, sparse infiltrates of lymphocytes in the septa, central lobular ischemic fat necrosis, and lipomembranous changes. Tissue cultures were negative. What therapeutic option can you offer this patient?
Surgical therapy
Graded elastic stockings
Topical antibiotics
Stanozolol
