WorksheetsCNS pharmacology (med students) Pt.2
Total questions: 13
Worksheet time: 6mins
The following pair of drug and inhibited enzyme can increase CNS bioavailability of levodopa (L-dopa):
Carbidopa -- Dopa decarboxylase
Carbidopa -- COMT
Entacapone -- Dopa decarboxylase
Entacapone -- COMT
Selegiline -- MAO(B)
Regarding MAO inhibitors:
Their clinical use requires dietary adjustments.
They are frequently used in primary care because of their safety profile.
They can interact with SSRIs to cause the serotonin syndrome.
They have severe and more frequent peripheral anticholinergic (atropine-like) side effects.
Phenelzine is an example.
Benzodiazepines are preferred over barbiturates because they do not cause dependence.
True
False
Barbiturates cause severe hangovers because they suppress both REM and non-REM sleep.
True
False
Benzodiazepines are preferred over barbiturates because they cause less respiratory depression.
True
False
Zolpidem is preferably used as a hypnotic agent because it does not affect sleep patterns.
True
False
Phenobarbital interacts with other drugs because it inhibits CYP450.
True
False
Regarding antipsychotic drugs:
Chlorpromazine is a typical antipsychotic drug.
Clozapine is an atypical antipsychotic drug.
Typical antipsychotic drugs are more effective for treatment of “positive” symptoms of schizophrenia than atypical agents.
Typical antipsychotics have fewer extrapyramidal adverse effects compared atypical.
Haloperidol causes hyperprolactinaemia.
Venlafaxine is an inhibitor of neuronal re-uptake of both norepinephrine and serotonin.
True
False
Fluoxetine is an MAO inhibitor.
True
False
Bupropion is a strong norepinephrine, but a weak dopamine, reuptake inhibitor.
True
False
Desipramine is an inhibitor of neuronal re-uptake of both norepinephrine and serotonin.
True
False
Phenelzine is a selective serotonin re-uptake inhibitor.
True
False
