WorksheetsCholinergic stimulants and blockers
Total questions: 13
Worksheet time: 9mins
The following drug and its therapeutic use is correctly matched:
Neostigmine - myasthenia gravis
Atropine - glaucoma
Ipratropium - asthma
Pilocarpine - organophosphate poisoning
The following drug is a directly acting cholinergic agonist
Neostigmine
Pilocarpine
Nicotine
Edrophonium
Pilocarpine
is a muscarinic cholinergic agonist
causes fixed accommodation
is used in treating glaucoma
causes dry eye
Cholinergic agonists
increase salivation
relax urinary bladder sphincter
increase heart rate
cause pupillary constriction
Atropine use is contraindicated in patients with
mushroom poisoning
organophosphate poisoning
glaucoma
bradycardia
Signs of atropine poisoning include
hyperthermia
hyperhydrosis
urinary frequency
confusion
The effect of atropine and its mechanism is correctly matched:
Bronchodilation: relaxation of bronchial smooth muscle
Mydriasis - pupillary sphincter muscle contration
Urinary retention - increased urinary sphincter tone
Tachycardia - stimulation of SA node
Atropine
is a non-competitive antagonist
causes miosis
increases bronchial secretion
is used for the treatment of bradycardia
Scopolamine (hyoscine)
causes bradycardia
is used in motion sickness
acts on nicotinic receptors
causes bronchoconstriction
A 10-year-old was brought to the emergency with profuse sweating, vomiting, diarrhoea and blurred vision after incidental ingestion of unknown product. Examination revealed signs of cholinergic overstimulation but the patient’s muscle power was unaffected.
The MOST likely product incidentally ingested is
neostigmine
insecticide containing malathion
mushroom containing muscarine
edrophonium
A 58-year-old housewife was recently diagnosed with glaucoma and started on pilocarpine eye drop as part of her treatment.
The MOST likely effect of pilocarpine in the eye making it suitable for this condition is
spasm of accommodation.
iris sphincter muscle contraction.
aqueous humour outflow enhancement.
lacrimation.
A patient was prescribed atropine to treat his bradycardia. However due to prescription error, he was given an overdose of atropine injection. He was given diazepam to counteract one of the signs of atropine overdose.
The MOST likely sign this patient exhibit is
dehydration
seizure
mydriasis
urinary retention
A 5-year-old girl was found unconscious by her mother who suspected that the child had eaten some wild fruits from an abandoned garden. She was rushed to the hospital. On examination, she had tachycardia with dilated pupils. The emergency physician suspected that she had atropine poisoning.
The BEST drug to prescribe as an antidote in the above case is
acetylcholine
physostigmine
pilocarpine
pralidoxime
