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Habib Dad's review Q

Total questions: 19

Worksheet time: 12mins

Name
Class
Date
1.

The following rxn is catalyzed by

a)

Type III deiodinase

b)

Type II deiodinase

c)

Type I deiodinase

2.

WOTF statements about L-Thyroxine are correct?

a)

one chiral center

b)

negatively charged under physiological conditions

c)

amphoteric compound

d)

prohormone

3.

What is the name of the following thyroid drug?

a)

TSH

b)

TRH

c)

Levothyroxine

d)

Liothyronine

e)

PTU

4.

WOTF statements about Liothyronin (T3) pKa 8.4 are correct?

a)

Liothyronine has one chiral center. L isomer is the active isomer

b)

L-Thyroxine (T4) has longer half-life than Liothyronine (T3)

c)

Liothyronine is an active hormone

d)

Liothyronine is an amphoteric compound

e)

Liothyronine has a longer half-life (1 week) than L-thyroxineLiothyronine

5.

WOTF is/are pro-hormone (T4)?

a)
b)
c)
6.

Which function does this molecule have? Methimazole

a)

inhibits 5'-deiodinase enzyme

b)

inhibits 5-deiodinase enzyme

c)

inhibits TSH receptor

d)

inhibits TRH receptor

e)

inhibits thyroid peroxidase enzyme

7.

Which function does this molecule have? Propylthiouracil

a)

inhibits 5-deiodinase

b)

inhibits 5'-deiodinase

c)

inhibits thyroid peroxidase enzyme

d)

inhibits TRH receptor

e)

inhibits 2'-deiodinase enzyme

8.

Which of the following compounds is/are active hormone (T3)?

a)
b)
c)
9.

What is the name of the following drug?

a)

TSH

b)

Levothyroxine

c)

Liothyronine

d)

TRH

e)

PTU

10.

ALL of the following are truuu about Estradiol EXCEPT:

a)

Biosynthesis requires the key enzyme aromatase

b)

exhibiting high potentcy when administered parentally

c)

estradiol is a CHIRAL compound

d)

steroid analog

e)

exhibiting high potency when administered orally

11.

What is the purpose of the ethinyl group at C-17? Ethinyl estradiol

a)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C17 hydroxy group

b)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C3 hydroxyl group

c)

Ethinyl is a chemically inert group and prevent metabolic reduction of C17 hydroxyl group

d)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C17 alkyne group

e)

Ethinyl is a chemically inert group and prevent glucuronide conjugation of C17 hydroxyl group

12.

WOTF statements are truuu about Ethinyl estradiol and Mestranol?

a)

Mestranol is 3-O-methyl ether of Ethinyl estradiol

b)

Ethinyl estradiol undergoes extensive enterohepatic recycling

c)

Ethinyl estradiol undergoes extensive first-pass metabolism

d)

Mestranol is a prodrug of Ethinyl estradiol

e)

Mestranol is a prodrug

13.

The agonist potency of the exogenous estrogens

a)

Estradiol > Estriol > Estrone

b)

Estradiol > Estrone > Estriol

c)

Estriol > Estradiol > Estrone

d)

Estrone > Estradiol > Estriol

e)

Estrone > Estriol > Estradiol

14.

SATA: 7a-aminophenylthioandrost-dienedione

a)

synthetic testosterone

b)

aromatose inhibitior

c)

CYP19 inhibitor

d)

steroid analog

e)

inhibits the conversion of testosterone to estrogens

15.

SATA: Anastrozole

a)

synthetic testosterone

b)

triazole analog

c)

aromatose inhibitor

d)

inhibits the conversion of testosterone to estrogens

e)

CYP19 inhibitor

16.

SATA: Ethisterone

a)

synthetic testosterone

b)

synthetic progestin

c)

aromatase inhibitor

d)

15-fold more active than progesterone when administered orally

e)

steroid analog

17.

SATA: Norethindrone

a)

acetylation of 17b-OH of Norethindrone enhances progestin activity

b)

acetylation of 17b-OH of Norethindrone increases the duraction of action

c)

Norethindrone is a synthetic progestin

d)

Norethindrone is a steroid analog

e)

Norethindrone is an aromatose inhibitor

18.

SATA: Testosterone 17b-:

-propionate (less bulky)

-enanthate

-undecanote

-cyclopentylpropionate

-cypionate (bulky)

a)

Testosterone is more active when administered parentally than orally

b)

Testosterone 17b-propionate is avail for IM administration

c)

Testosterone 17b-enanthate is a prodrug

d)

Testosterone 17b-cypionate has a longer duration of action of 1-2 weeks

e)

Testosterone 17b-enanthate has a longer duration of action of 2-4 weeks

19.

SATA: Fluoxymestrone

a)

synthetic testosterone

b)

orally active

c)

aromatase inhibitor

d)

steroid analog

e)

the presence of 17a alkyl group reduces susceptibility to hepatic oxidative metabolism