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WorksheetsUnit 4, Final Part 1
Total questions: 19
Worksheet time: 14mins
1. The branch of medicine that focuses on how a person's genetic profile impacts how drugs interact with their body is known as...
gene therapy
pharmacogenomics
retroviral therapy
CRISPR Cas9
What is meant by the term "genetic disorder"?
Any condition or disease that is caused by a virus
Any condition or disease that is caused by a bacteria
Any condition or disease caused by a mutation to DNA
All of the described reasons
Gene expression is when...
genes have a positive effect on the body.
genes have a negative effect on the body.
ribosomes follow the genetic recipe provided by mRNA to make a protein.
the nucleus makes proteins according to the coded information received from viral genetic material.
Which of the following best describes a gene expression profile?
The presence of a gene in a person's genetic profile.
All of the genes in a person's body.
All of the genes that are "turned on" in a person's body.
All of the genes that are "turned on" in a particular type of cell.
5. A gene variant that doctors and researchers are not sure about its impact on disease is known as a...
variant of unknown significance (VUS)
pathogenic variant
benign variant
vastly underestimated supergene (VUSG)
6. What kind of genetic material carries the code for a protein from the nucleus?
DNA
mRNA
tRNA
snRNA
A genetic condition where someone has too many copies of a chromosome is called...
trisomy.
monosomy.
aneuploidy.
haploidly.
When one or more nucleotide bases are missing from the DNA sequence and the protein is affected, it is known as a...
chromosome anomaly.
deletion.
duplication.
inversion.
When a genetic disorder is due to changes on the 23rd chromosome, it is referred to a...
autosomal disorder.
monosomal disorder.
germ line disorder.
sex-linked disorder.
A medical professional that consults with individuals and families that have been diagnosed with a genetic disorder is known as a...
gene therapist.
gene therapy consultant.
genetic counselor.
genetic manipulator.
Adding a corrected version of a gene or modifying a defective gene to make it work properly is also known as...
gene therapy.
genetic splicing.
gene doping.
genetic counseling.
Which of the following would EXCLUDE a genetic disease from being a good candidate for gene therapy?
a disease that is due to a single nucleotide base mutation.
a disease that is well understood.
a disease where the genes involved were well known.
a disease that is caused by many genes spread over many chromosomes.
Which of the following best describes ex-vivo gene therapy?
Therapy that involves removing tissues and cells from the body, performing a treatment, and then returning the tissues and cells to the body
Therapy that involves the use of x-rays to mutate the genes within specific tissues within the body.
Therapy that involves injecting drugs into the cells and tissues within the body to cause changes in the DNA.
Therapy that involves the injection of nano-machines into the body to cause modifications to specific genes.
In the CRISPR Cas9 approach to modifying genes, Cas9 is often referred to as the...
guide for where the cut in the DNA is to be made.
holder of the genetic information that is to inserted into the DNA.
"glue" that holds the CRISPR molecule to the DNA sequence.
"scissors" that cut the DNA at a specific site.
The CRISPR Cas9 system was developed from...
a dream by Sheldon Cooper, a research scientist at Caltech.
the immune system of bacteria in their billion-year-long war against viruses.
a special protein found in the DNA of yeasts.
research into the development of nano-machines that could repair red blood cells.
Scientists can program where the Cas9 enzyme will cut by inserting ______________________ that can be matched up with the DNA, thereby telling the Cas9 enzyme where to cut.
PAM
GPS locator proteins
Fidelco guide dogs
guide RNA
In the human genome, guanine-guanine repeats preceded by any nucleotide (n) are referred to as ______________ and are used to help guide the CRISPR Cas9 complex to particular locations on the DNA.
HHPE
MSAFP
LOL
PAM
What is a major advantage for CRISPR Cas 9 when compared to regular gene therapies?
it is very specific about where it will cut the DNA
it is easily programmable to carry genetic information of many different sizes.
it can be used either en-vivo or ex-vivo
All of the above are advantages of CRISPR Cas9
As in the normal manufacture of proteins in cells, the CRISPR Cas9 complex makes use of ____________ to put together amino acids to make the protein.
tRNA
mRNA
DNA
cDNA
