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WorksheetsMTM May 22 Week 4 Genetics
Total questions: 20
Worksheet time: 27mins
When a cytogenetic abnormality is suspected in an infant with multiple congenital anomalies, chromosomes from circulating leukocytes are analyzed. These chromosomes are most condensed and easiest to evaluate in which of the following states?
Anaphase
Interphase
Metaphase
Prophase
Telophase
True or false: Trisomies of sex chromosomes are more likely to survive to gestation than autosomal trisomies.
True
False
The pedigree below tracks the presence of dimples through a family's generation. Having dimples is an autosomal dominant trait. If individual III-3 married a woman who was heterozygous for dimples, what is the percent chance their children will have dimples?
0%
25%
50%
75%
100%
An experimenter obtains tissue samples from a normal 80-year-old patient and a normal 25-year-old patient and grows fibroblasts from these samples in an in vitro cell culture system. She finds that cells from the older patient stop dividing much sooner than cells from the younger patient. This finding is most likely explained by a difference in which of the following?
circulating levels of cytokines
growth factor activity
hormonal level
oncogene expression
telomere length
Scientists studying aneuploidy identify a substance that inhibits chromosomal separation of chromosome 21 during Meiosis I. If women exposed to this substance become pregnant, their zygotes may have which of the following numbers of chromosomes?
45
43
46
48
44
Are prokaryotic genes polycistronic?
Yes
No
Depends on multiple factors
Only at times
Only during mitosis
The “crossing-over” observed
between chromosomal arms
during human meiosis is better
termed:
Homologous recombination
Polygenic resegregation
Polyclonal diversification
Combinatorial segmentation
Nonrandom assortment
Which of the following statements correctly describes eukaryotic nuclear chromosomal DNA?
Each discontinuous piece making up the chromosomes of eukaryotes is about the same size as each prokaryotic chromosome
Unlike bacterial DNA, no histones are associated with it
It is not replicated semiconservatively
It is a linear and unbranched molecule
It is not associated with a specific membranous organelle
What is the inheritance pattern?
Autosomal Recessive
X-linked Dominant
Mitochondrial
Autosomal Dominant
X-linked Recessive
What is the product of Meiosis I?
An egg or sperm cell
Two diploid cells containing bivalent chromosomes
Four haploid cells containing monovalent chromosomes
Two haploid cells containing bivalent chromosomes
Four diploid cells containing tetravalent chromosomes
As a general rule, new, spontaneous
mutations occurring in a child will occur
more often on the paternal than maternal
chromosomes. Why is this?
DNA repair is weaker in spermatocytes than oocytes
Fathers have shorter life expectancies than mothers
More cell divisions occur in spermatogenesis than oogenesis
Mitochondria are inherited only from mothers
Essential DNA repair genes are found on the X chromosome
This is a pedigree for a family with a history of Cystic Fibrosis. The III-2 female is affected with CF. What is the probability that her sister (marked by the arrow) is a carrier of CF?
50%
75%
33%
25%
66%
If a spontaneous mutation occurs in an
individual, that mutation will only be passed
onto the individual’s offspring if it occurs in
the...
Central Nervous System
Heart
Bone Marrow
Germline
They are in all tissues
What is the inheritance pattern?
Autosomal Recessive
X-linked Dominant
Mitochondrial
Autosomal Dominant
X-linked Recessive
A 24-year-old at 22 weeks gestation presents for prenatal ultrasound testing. Imaging shows a female fetus with a fluid-filled sac near the base of the head. Amniocentesis show the presence of 45 fetal chromosomes. Which of the following conditions is indicated?
Klinefelter Syndrome
Edward’s Syndrome
Down Syndrome
Turner Syndrome
An individual is affected by an autosomal recessive disease. What is the probability that his unborn sibling will be a carrier of the AR disease?
50%
75%
33%
25%
66%
A promoter site on DNA
Transcribes repressor
Initiates transcription
Codes for RNA polymerase
Regulates termination
Translates specific proteins
Which disease would follow this inheritance pattern?
Sickle Cell
Fragile X
MELAS
Achondroplasia
Hemophilia
What molecule carries the basic genetic information within a human cell?
Double-helical collagen protein
Double-stranded DNA
A multitude of protein molecules
A multitude of lipid molecules
Linear carbohydrate molecules
The pedigree below tracks Duchenne Muscular Dystrophy (DMD) through several generations. DMD is an X-linked recessive trait. If individual II-3 has a child with a carrier woman, what is the percent chance that the child will be a daughter with DMD?
0%
25%
50%
75%
100%
