WorksheetsSPARTAN QUIZ 2
Total questions: 10
Worksheet time: 5mins
What are the trials that were able to meet primary endpoint?
TRANSFORM-1 and SUSTAIN-1
TRANSFORM-2 and SUSTAIN-1
TRANSFORM-1 and SUSTAIN-2
TRANSFORM-2 and SUSTAIN-2
In MADRS, the minimal clinically important difference (MCID) is a score change of between:
1.6 and 1.9 points
1.7 and 2.0 points
1.5 and 1.8 points
1.4 and 1.7 points
How many items are there in the Montgomery-Asberg Depression Rating Scale?
7 items
8 items
10 items
11 items
In the clinical trials, response rate is defined as:
More than or equal to 40% improvement on MADRS from baseline
More than or equal to 50% improvement on MADRS from baseline
More than or equal to 60% improvement on MADRS from baseline
More than or equal to 70% improvement on MADRS from baseline
In general, remission rate is defined as:
MADRS total score of less than or equal to 9
MADRS total score of less than or equal to 11
MADRS total score of less than or equal to 12
MADRS total score of less than or equal to 13
In SUSTAIN-1, relapse is defined as:
MADRS total score of more than or equal to 19 for 2 consecutive assessments
MADRS total score of more than or equal to 22 for 3 consecutive assessments
MADRS total score of more than or equal to 19 for 3 consecutive assessments
MADRS total score of more than or equal to 22 for 2 consecutive assessments
In SUSTAIN-2, patients were recruited by:
Direct-entry patients only
Direct-entry and transferred-entry patients
Transferred-entry patients only
None of the above
In SUSTAIN-2, primary objectives included assessing long-term safety and tolerability by assessing:
Potential effects on cognitive function
Potential treatment-emergent symptoms of cystitis
Potential withdrawal and/or rebound symptoms following cessation of intranasal esketamine treatment
All of the above
Non-responder is defined as:
Less than or equal to 15% improvement in MADRS score
Less than or equal to 20% improvement in MADRS score
Less than or equal to 25% improvement in MADRS score
Less than or equal to 30% improvement in MADRS score
In TRANSFORM-2, the primary endpoint was:
Change in MADRS total score from Day 1 to Day 2
Change in MADRS total score from Day 1 to Day 4
Change in MADRS total score from Day 1 to Day 7
Change in MADRS total score from Day 1 to Day 28
