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WorksheetsQuiz 4_physiological & Patphysiological Signals_Cancer_UTM2022
Total questions: 11
Worksheet time: 6mins
Which of these are negative regulator genes of oncogenesis?
I) OCT4 II) p53 III) NANOG IV) Rb
I and II
II and IV
II and III
III and IV
What type of mutation does the figure represent?
Insertion
Deletion
Translocation
Duplication
Differentiate a. Physiology b. Pathology
a. Physiology of abnormal state
b. Nature of a disease
a. Nature of a disease
b. Physiology of abnormal state
a. Physiology of abnormal state
b. normal function of an organ/part of the body
a. normal function of an organ/part of the body
b. Nature of a disease
What are the 1st and 5th events in the cancer hallmark?
Sustaining proliferation signals & replicative immortality
evading growth repressors & metastasis
Resisting cell death & angiogenesis
Sustaining proliferation signals & angiogenesis
evading growth repressors & resisting cell death
Which of these are markers for anginogenesis?
vimentin
PDGF
E-cadherin
VEGF
p53
Proto-oncogenes cause uncontrolled cell growth and metastasis
True
False
A breast tumor biopsy result showed elevated expression of a gene responsible for telomerase activity. Point out the possible fate of the cancer/cancer patient
breast cancer stage 2/3
brain metastasis
tumor cells are undergoing unlimited cell division
Palliative care
A screening on a sample of tumor tissue revealed that an apoptotic gene was heavily methylated. Choose relevant facts related to the event above.
this event/condition is irreversible
deletion of p53 gene related nucleotide base
tumor caused by epigenetic modification
inhibition of the apoptotic protein production
Tina has a small lump of about 1-2cm in length located on her left breast . A biopsy was done and it showed that the estrogen receptor (ER) expression was very high. As a doctor, how would u diagnose her cancer.
high recovery rate via targeted therapy
Stage 1 pancreatic cancer
the tumor is insensitive to growth signals
Tina will undergo the HER2 targeted therapy
Which of these refer to EMT?
induce tumor metastasis to distal areas in the body
tumor cells loose its epithelial function
tumor cells express high levels of E-cadherin & low levels of vimentin
tumor cells posses stem cell like characteristics
tumor cells undergo conversion from non specialized to specialized cells
how would you describe a protooncogene?
formation & maintenance of new blood vessels
oncogene in a nonmutant state
can be altered & become oncogene-uncontrolled growth
resist cell death
