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Anthelmintic Drugs

Total questions: 26

Worksheet time: 13mins

Name
Class
Date
1.

A 32-year-old man is diagnosed with whipworm disease after he spent the summer working outside with· out shoes. Which would be the best treatment option?

a)

Pyrantel pamoate

b)

Mebendazole

c)

Thiabendazole

d)

Diethylcarbamazine

2.

Which combination would be appropriate to use for preventative chemotherapy in countries with endemic filariasis and endemic onchocerciasis?

a)

Pyrantel pamoate and mebendazole

b)

lvermectin and diethylcarbamazine

c)

Albendazole and diethylcarbamazine

d)

lvermectin and albendazole

3.

Which statement best describes the mechanism of action of pyrantel pamoate

a)

Acts as a depolarizing neuromuscular blocking agent leading to paralysis of the worm

b)

Binds to p-tubulin and inhibits the assembly of the microtubules polymerization in the parasite

c)

Inhibits the mitochondrial phosphorylation of adenosine diphosphate (ADP) in the parasite

d)

Inhibits glucose uptake leading to parasite death

4.

Which is the best treatment option for treatment of cutaneous larva migrans? A. Pyrantel pamoate B. Diethylcarbamazine C. lvermectin D. Niclosamide

a)

Pyrantel pamoate

b)

Diethylcarbamazine

c)

lvermectin

d)

Niclosamide

5.

Which medication used to treat river blindness targets chloride channels and can cause a Mazzoni reaction? A. lvermectin B. Praziquantel C. Pyrantel pamoate D. Albendazole

a)

lvermectin

b)

Praziquantel

c)

Pyrantel pamoate

d)

Albendazole

6.

A 48-year-old immigrant from Mexico presents with seizures and other neurologic symptoms. Eggs of Taenia solium are found in a stool specimen. A magnetic resonance image of the brain shows many cysts, some of which are calcified. Which drug would be of benefit to this individual?

a)

lvermectin

b)

Pyrantel pamoate

c)

Albendazole

d)

Diethylcarbamazine

7.

Which drug works by increasing the permeability of the cell membrane to calcium

a)

Albendazole

b)

lvermectin

c)

Niclosamide

d)

Praziquantel

8.

When used for treatment of taeniasis, a laxative is usually administered prior to oral administration of which drug?

a)

Mebendazole

b)

Diethylcarbamazine

c)

Niclosamide

d)

Pyrantel pamoate

9.

A 37-year-old man presents with diarrhea and gastrointestinal bleeding. Eggs of Schistosoma mansoni are found upon examination of a stool specimen. The patient has a history of seizures and is currently on phenytoin. Metabolism of which medication will be increased due to his current drug regimen? A lvermectin B. Praziquantel C. Thiabendazole D. Niclosamide

a)

lvermectin

b)

Praziquantel

c)

Thiabendazole

d)

Niclosamide

10.

When used for longer treatment, such as hydatid disease, which medication is associated with risks of hepatotoxicity and agranulocytosis?

a)

Albendazole

b)

Diethylcarbamazine

c)

Niclosamide

d)

lvermectin

11.

Tick the drug, blocking acetylcholine transmission at the myoneural junction of helminthes

a)

Levamisole

b)

Mebendazole

c)

Piperazine

d)

Niclosamide

12.

Tick niclosamide mechanism of action: a) Increasing cell membrane permeability for calcium, resulting in paralysis, dislodgement and death of helminthesb) Blocking acetylcholine transmission at the myoneural junction and paralysis of helminthes c) Inhibiting microtubule synthesis in helminthes and irreversible impairment of glucose uptake d) Inhibiting oxidative phosphorylation in some species of helminthes

a)

Increasing cell membrane permeability for calcium, resulting in paralysis, dislodgement and death of helminthes

b)

Blocking acetylcholine transmission at the myoneural junction and paralysis of helminthes

c)

Inhibiting microtubule synthesis in helminthes and irreversible impairment of glucose uptake

d)

Inhibiting oxidative phosphorylation in some species of helminthes

13.

Tick praziquantel mechanism of action

a)

Blocking acetylcholine transmission at the myoneural junction and paralysis of helminthes

b)

Inhibiting microtubule synthesis in helminthes and irreversible impairment of glucose uptake

c)

Increasing cell membrane permeability for calcium, resulting in paralysis, dislodgement and death ofhelminthes

d)

Inhibiting oxidative phosphorylation in some species of helminthes

14.

Tick piperazine mechanism of action

a)

Inhibiting microtubule synthesis in helminthes and irreversible impairment of glucose uptake

b)

Blocking acetylcholine transmission at the myoneural junction and paralysis of helminthes

c)

Inhibiting oxidative phosphorylation in some species of helminthes

d)

Increasing cell membrane permeability for calcium, resulting in paralysis, dislodgement and death of helminthes

15.

Tick the drug, a salicylamide derivative:

a)

Praziquantel

b)

Piperazine

c)

Mebendazole

d)

Niclosamide

16.

Tick mebendazole mechanism of action: a) Inhibiting oxidative phosphorylation in some species of helminthes b) Increasing cell membrane permeability for calcium, resulting in paralysis, dislodgement and death of helminthesc) Inhibiting microtubule synthesis in helminthes and irreversible impairment of glucose uptake d) Blocking acetylcholine transmission at the myoneural junction and paralysis of helminthes

a)

Inhibiting oxidative phosphorylation in some species of helminthes

b)

Increasing cell membrane permeability for calcium, resulting in paralysis, dislodgement and death of helminthes

c)

Inhibiting microtubule synthesis in helminthes and irreversible impairment of glucose uptake

d)

Blocking acetylcholine transmission at the myoneural junction and paralysis of helminthes

17.

Tick the drug, inhibiting oxidative phosphorylation in some species of helminthes:

a)

Niclosamide

b)

Piperazine

c)

Praziquantel

d)

Mebendazole

18.

Tick the drug for neurocysticercosis treatment: a) Praziquantel b) Pyrantel c) Piperazine d) Bithionol

a)

A

b)

B

c)

C

d)

D

19.

Tick the drug for nematodosis (roundworm invasion) treatment: a) Niclosamide b) Praziquantel c) Bithionol d) Pyrantel

a)

A

b)

B

c)

C

d)

D

20.

Tick the drug for cestodosis (tapeworm invasion) treatmen

a)

Piperazine

b)

Praziquantel

c)

Pyrantel

d)

Ivermectin

21.

Tick the drug for trematodosis (fluke invasion) treatment:

a)

Bithionol

b)

Ivermectin

c)

Pyrantel

d)

Metronidazole

22.

Tick the drug, a benzimidazole derivative: a) Praziquantel b) Mebendazole c) Suramin d) Pyrantel

a)

Praziquantel

b)

Mebendazole

c)

Suramin

d)

Pyrantel

23.

Tick the broad spectrum drug for cestodosis, trematodosis and cycticercosis treatment

a)

Piperazine

b)

Ivermectine

c)

Praziquantel

d)

Pyrantel

24.

Tick the drug for ascaridosis and enterobiosis treatment:

a)

Bithionol

b)

Pyrantel

c)

Praziquantel

d)

Suramin

25.

Tick the drug for strongiloidosis treatment:

a)

Niclosamide

b)

Praziquantel

c)

Bithionol

d)

Ivermectin

26.

Tick the drug for echinococcosis treatment:

a)

Suramin

b)

Mebendazole or Albendazole

c)

Piperazine

d)

Iodoquinol