WorksheetsCholinergic 2
Total questions: 25
Worksheet time: 13mins
Which of the following direct-acting cholinomimetics has the shortest duration of action?
Acetylcholine
Methacholine
Carbachol
Bethanecho
Bethanechol has all of the following properties EXCEPT:
It is extremely resistant to hydrolysis
Purely muscarinic in its action
It is used for abdominal urinary bladder distention
It exerts both nicotinic and muscarinic effects
A M-cholinimimetic agent is:
Carbachol
Pilocarpine
Acetylcholine
Bethanechol
Characteristics of pilocarpine include all of the following EXCEPT:
It is a tertiary amine alkaloid
It causes miosis and a decrease in intraocular pressure
Causes a decrease in secretory and motor activity of gut
It is useful in the treatment of glaucoma
Which of the following cholinomimetics is a plant derivative with lower potency than nicotine but with a similar spectrumof action?
Lobeline
Pilocarpine
Carbochol
Acetylcholine
Which of the following cholinomimetics is indirect-acting?
Lobeline
Edrophonium
Pilocarpine
Carbacho
The mechanism of action of indirect-acting cholinomimetic agents is:
Binding to and activation of muscarinic or nicotinic receptors
Inhibition of the hydrolysis of endogenous acetylcholine
Stimulation of the action of acetylcholinesterase
Releasing acetylcholine from storage sites
Indicate a reversible cholinesterase inhibitor:
Isoflurophate
Carbochol
Physostigmine
Parathion
Which of the following cholinesterase inhibitors is irreversible?
Physostigmine
Edrophonium
Neostigmine
Isoflurophate
Indicate cholinesterase activator:
Pralidoxime
Edrophonium
Pilocarpine
Isoflurophate
Isofluorophate increases all of the following effects except:
Lacrimation
Bronchodilation
Muscle twitching
Salivation
Indicate a cholinesterase inhibitor, which has an additional direct nicotinic agonist effect:
Edrophonium
Carbochol
Neostigmine
Lobeline
Сholinesterase inhibitors do not produce: a) Bradycardia, no change or modest fall in blood pressure b) Increased strength of muscle contraction, especially in muscles weakened by myasthenia gravis c) Miosis and reduction of intraocular pressure d) Dramatic hypertension and tachycardia
Bradycardia, no change or modest fall in blood pressure
ncreased strength of muscle contraction, especially in muscles weakened by myasthenia gravi
Miosis and reduction of intraocular pressure
Dramatic hypertension and tachycardia
Which of the following cholinomimetics is commonly used in the treatment of glaucoma?
Pilocarpine
Lobeline
Acethylcholine
Neostigmine
Indicate the organophosphate cholinesterase inhibitor, which can be made up in an aqueous solution for ophthalmicuseand retains its activity within a week:
Physoctigmine
Edrophonium
Echothiophate
Neostigmine
Which of the following cholinomimetics is most widely used for paralytic ileus and atony of the urinary bladder?
Lobeline
Neostigmine
Pilocarpine
Echothiophate
Chronic long-term therapy of myasthenia is usually accomplished with:
Edrophonium
Neostigmine
Echothiophate
Carbachol
Which of the following cholinomimetics is a drug of choice for reversing the effects of nondepolarizing neuromuscularrelaxants?
Echothiophate
Physostigmine
Edrophonium
Pilocarpine
Indicate the reversible cholinesterase inhibitor, which penetrates the blood-brain barrier:
Physostigmine
Edrophonium
Neostigmine
Piridostigmine
Which of the following cholinomimetics is used in the treatment of atropine intoxication?
Neostigmine
Carbochol
Physostigmine
Lobeline
The symptoms of excessive stimulation of muscarinic receptors include all of the following EXCEPT:
Abdominal cramps, diarrhea
Increased salivation, excessive bronchial secretion
Miosis, bradycardia
Weakness of all skeletal muscles
The excessive stimulation of muscarinic receptors by pilocarpine and choline esters is blocked competitively by:
Edrophonium
Atropine
Pralidoxime
Echothiophate
The toxic effects of a large dose of nicotine include all of the following EXCEPT:
Convulsions, coma and respiratory arrest
Hypotension and bradycardia
Skeletal muscle depolarization blockade and respiratory paralysis
Hypertension and cardiac arrhythmias
The dominant initial sights of acute cholinesterase inhibitors intoxication include all of the following except:
Salivation, sweating
Mydriasis
Bronchial constriction
Vomiting and diarrhea
Which of the following drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?
Atropine
Pilocarpine
Pralidoxime
Edrophonium
