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Cholinergic 2

Total questions: 25

Worksheet time: 13mins

Name
Class
Date
1.

Which of the following direct-acting cholinomimetics has the shortest duration of action?

a)

Acetylcholine

b)

Methacholine

c)

Carbachol

d)

Bethanecho

2.

Bethanechol has all of the following properties EXCEPT:

a)

It is extremely resistant to hydrolysis

b)

Purely muscarinic in its action

c)

It is used for abdominal urinary bladder distention

d)

It exerts both nicotinic and muscarinic effects

3.

A M-cholinimimetic agent is:

a)

Carbachol

b)

Pilocarpine

c)

Acetylcholine

d)

Bethanechol

4.

Characteristics of pilocarpine include all of the following EXCEPT:

a)

It is a tertiary amine alkaloid

b)

It causes miosis and a decrease in intraocular pressure

c)

Causes a decrease in secretory and motor activity of gut

d)

It is useful in the treatment of glaucoma

5.

Which of the following cholinomimetics is a plant derivative with lower potency than nicotine but with a similar spectrumof action?

a)

Lobeline

b)

Pilocarpine

c)

Carbochol

d)

Acetylcholine

6.

Which of the following cholinomimetics is indirect-acting?

a)

Lobeline

b)

Edrophonium

c)

Pilocarpine

d)

Carbacho

7.

The mechanism of action of indirect-acting cholinomimetic agents is:

a)

Binding to and activation of muscarinic or nicotinic receptors

b)

Inhibition of the hydrolysis of endogenous acetylcholine

c)

Stimulation of the action of acetylcholinesterase

d)

Releasing acetylcholine from storage sites

8.

Indicate a reversible cholinesterase inhibitor:

a)

Isoflurophate

b)

Carbochol

c)

Physostigmine

d)

Parathion

9.

Which of the following cholinesterase inhibitors is irreversible?

a)

Physostigmine

b)

Edrophonium

c)

Neostigmine

d)

Isoflurophate

10.

Indicate cholinesterase activator:

a)

Pralidoxime

b)

Edrophonium

c)

Pilocarpine

d)

Isoflurophate

11.

Isofluorophate increases all of the following effects except:

a)

Lacrimation

b)

Bronchodilation

c)

Muscle twitching

d)

Salivation

12.

Indicate a cholinesterase inhibitor, which has an additional direct nicotinic agonist effect:

a)

Edrophonium

b)

Carbochol

c)

Neostigmine

d)

Lobeline

13.

Сholinesterase inhibitors do not produce: a) Bradycardia, no change or modest fall in blood pressure b) Increased strength of muscle contraction, especially in muscles weakened by myasthenia gravis c) Miosis and reduction of intraocular pressure d) Dramatic hypertension and tachycardia

a)

Bradycardia, no change or modest fall in blood pressure

b)

ncreased strength of muscle contraction, especially in muscles weakened by myasthenia gravi

c)

Miosis and reduction of intraocular pressure

d)

Dramatic hypertension and tachycardia

14.

Which of the following cholinomimetics is commonly used in the treatment of glaucoma?

a)

Pilocarpine

b)

Lobeline

c)

Acethylcholine

d)

Neostigmine

15.

Indicate the organophosphate cholinesterase inhibitor, which can be made up in an aqueous solution for ophthalmicuseand retains its activity within a week:

a)

Physoctigmine

b)

Edrophonium

c)

Echothiophate

d)

Neostigmine

16.

Which of the following cholinomimetics is most widely used for paralytic ileus and atony of the urinary bladder?

a)

Lobeline

b)

Neostigmine

c)

Pilocarpine

d)

Echothiophate

17.

Chronic long-term therapy of myasthenia is usually accomplished with:

a)

Edrophonium

b)

Neostigmine

c)

Echothiophate

d)

Carbachol

18.

Which of the following cholinomimetics is a drug of choice for reversing the effects of nondepolarizing neuromuscularrelaxants?

a)

Echothiophate

b)

Physostigmine

c)

Edrophonium

d)

Pilocarpine

19.

Indicate the reversible cholinesterase inhibitor, which penetrates the blood-brain barrier:

a)

Physostigmine

b)

Edrophonium

c)

Neostigmine

d)

Piridostigmine

20.

Which of the following cholinomimetics is used in the treatment of atropine intoxication?

a)

Neostigmine

b)

Carbochol

c)

Physostigmine

d)

Lobeline

21.

The symptoms of excessive stimulation of muscarinic receptors include all of the following EXCEPT:

a)

Abdominal cramps, diarrhea

b)

Increased salivation, excessive bronchial secretion

c)

Miosis, bradycardia

d)

Weakness of all skeletal muscles

22.

The excessive stimulation of muscarinic receptors by pilocarpine and choline esters is blocked competitively by:

a)

Edrophonium

b)

Atropine

c)

Pralidoxime

d)

Echothiophate

23.

The toxic effects of a large dose of nicotine include all of the following EXCEPT:

a)

Convulsions, coma and respiratory arrest

b)

Hypotension and bradycardia

c)

Skeletal muscle depolarization blockade and respiratory paralysis

d)

Hypertension and cardiac arrhythmias

24.

The dominant initial sights of acute cholinesterase inhibitors intoxication include all of the following except:

a)

Salivation, sweating

b)

Mydriasis

c)

Bronchial constriction

d)

Vomiting and diarrhea

25.

Which of the following drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?

a)

Atropine

b)

Pilocarpine

c)

Pralidoxime

d)

Edrophonium