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Worksheets

Ach block

Total questions: 45

Worksheet time: 23mins

Name
Class
Date
1.

Atropine causes:

a) Spasmolitic activity

b) Intestinal hypermotility

c) Stimulation of contraction in the gut

d) Stimulation of secretory activity

a)

Spasmolitic activity

b)

Intestinal hypermotility

c)

Stimulation of contraction in the gut

d)

Stimulation of secretory activity

2.

Which of the following drugs is useful in the treatment of uterine spasms?

a)

Carbachol

b)

Vecuronium

c)

Atropine

d)

Edrophonium

3.

Atropine may cause a rise in body temperature (atropine fever):

a)

In adults

b)

In pregnant women

c)

In infants and children

d)

All of the above

4.

The pharmacologic actions of scopolamine most closely resemble those of:

a)

Hexamethonium

b)

Atropine

c)

Succinylcholine

d)

Pilocarpine

5.

Compared with atropine, scopolamine has all of the following properties EXCEPT:

a)

More marked central effect

b)

Less potent in decreasing bronchial, salivary and sweat gland secretion

c)

More potent in producing mydriasis and cycloplegia

d)

Lower effects on the heart, bronchial muscle and intestines

6.

Which of the following drugs is useful in the treatment of Parkinson′s disease?

a)

Benztropine

b)

Edrophonium

c)

Succinylcholine

d)

Hexamethonium

7.

Indicate the antimuscarinic drug, which is used as a mydriatic:

a)

Pilocarpine

b)

Neostigmine

c)

Homatropine

d)

Ipratropium

8.

Which of the following agents is used as an inhalation drug in asthma?

a)

Atropine

b)

Ipratropium

c)

Lobeline

d)

Homatropine

9.

Which of the following agents is most effective in regenerating cholinesterase associated with skeletal muscle

neuromuscular junctions?

a)

Suscinilcholine

b)

Pralidoxime

c)

Pirenzepine

d)

Propiverine

10.

Indicate an antimuscarinic drug, which is effective in the treatment of mushroom poising:

a)

Pralidoxime

b)

Pilocarpine

c)

Homatropine

d)

Atropine

11.

Antimuscarinics are used in the treatment of the following disorders EXCEPT:

a)

Motion sickness

b)

Glaucoma

c)

Hyperhidrosis

d)

Asthma

12.

The atropine poisoning includes all of the following symptoms EXCEPT:

a)

Mydriasis, cycloplegia

b)

Hyperthermia, dry mouth, hot and flushed skin

c)

Agitation and delirium

d)

Bradicardia, orthostatic hypotension

13.

The treatment of the antimuscarinic effects can be carried out with:

a)

Neostigmine

b)

Hexametonium

c)

Homatropine

d)

Acetylcholine

14.

Contraindications to the use of antimuscarinic drugs are all of the following except:

a) Glaucoma

b) Myasthenia

c) Bronchial asthma

d) Paralytic ileus and atony of the urinary bladder

a)

Glaucoma

b)

Myasthenia

c)

Bronchial asthma

d)

Paralytic ileus and atony of the urinary bladder

15.

Hexamethonium blocks the action of acethylcholine and similar agonists at:

a)

Muscarinic receptor site

b)

Neuromuscular junction

c)

Autonomic ganglia

d)

Axonal transmission

16.

The applications of the ganglion blockers have disappeared because of all of the following reasons EXCEPT:

a)

Orthostatic hypotension

b)

Lack of selectivity

c)

Homeostatic reflexes block

d)

Respiratory depression

17.

Which of the following agents is a short-acting ganglion blocker?

a)

Homatropine

b)

Trimethaphane

c)

Hexamethonium

d)

Pancuronium

18.

Indicate the ganglion-blocking drug, which can be taken orally for the treatment of hypertension?

a)

Mecamylamine

b)

Scopolamine

c)

Trimethaphane

d)

Vecocuronium

19.

The systemic effects of hexamethonium include all of the following EXCEPT

a)

Reduction of both peripheral vascular resistance and venous return

b)

Partial mydriasis and loss of accommodation

c)

Constipation and urinary retention

d)

Stimulation of thermoregulatory sweating

20.

Ganglion blocking drugs are used for the following emergencies EXCEPT:

a) Hypertensive crises

b) Controlled hypotension

c) Cardiovascular collapse

d) Pulmonary edema

a)

Hypertensive crises

b)

Controlled hypotension

c)

Cardiovascular collapse

d)

Pulmonary edema

21.

Agents that produce neuromuscular blockade act by inhibiting

a)

Interaction of acetylcholine with cholinergic receptors

b)

Release of acetylcholine from prejunctional membrane

c)

Packaging of acetylcholine into synaptic vesicles

d)

Reuptake of acetylcholine into the nerve ending

22.

Skeletal muscle relaxation and paralysis can occur from interruption of functions at several sites, including all of the

following EXCEPT

a)

Nicotinic acethylcholine receptors

b)

Muscarinic acethylcholine receptors

c)

The motor end plate

d)

Contractile apparatus

23.

Nondepolarisation neuromuscular blocking agents:

a)

Block acetylcholine reuptake

b)

Prevent access of the transmitter to its receptor and depolarization

c)

Block transmission by an excess of a depolarizing stagoni

d)

All of the above

24.

Which of the following drugs has “double-acetylcholine” structure?

a)

Rocuronium

b)

Carbachol

c)

Atracurium

d)

Succylcholine

25.

Indicate the long-acting neuromuscular blocking agent:

a)

Rapacuronium

b)

Mivacurium

c)

Tubocurarine

d)

Rocuronium

26.

Which of the following neuromuscular blocking drugs is an intermediate-duration muscle relaxant?

a)

Vecuronium

b)

Tubocurarine

c)

Pancuronium

d)

Rapacuronium

27.

Indicate the nondepolarizing agent, which has the fastest onset of effect?

a)

Succinylcholine

b)

Rapacuronium

c)

Pancuronium

d)

Tubocurarine

28.

Indicate the neuromuscular blocker, whose breakdown product readily crosses the blood-brain barrier and may cause

seizures:

a)

Pancuronium

b)

Succinylcholine

c)

Tubocurarine

d)

Atracurium

29.

Which competitive neuromuscular blocking agent could be used in patients with renal failure?

a)

Atracurium

b)

Succinylcholine

c)

Pipecuronium

d)

Doxacurium

30.

Indicate the nondepolarizing agent, which has short duration of action:

a)

Succinylcholine

b)

Tubocurarine

c)

Mivacurium

d)

Pancuronium

31.

Which depolarizing agent has the extremely brief duration of action?

a)

Mivacurium

b)

Rapacuronium

c)

Rocuronium

d)

Succinylcholine

32.

Neuromuscular blockade by both succinylcholine and mivacurium may be prolonged in patients with:

a) Renal failure

b) An abnormal variant of plasma cholinesterase

c) Hepatic disease

d) Both b and c

a)

Renal failure

b)

An abnormal variant of plasma cholinesterase

c)

Hepatic disease

d)

An abnormal variant of plasma cholinesterase

Hepatic disease

33.

Depolarizing agents include all of the following properties EXCEPT:

a)

Interact with nicotinic receptor to compete with acetylcholine without receptor activation

b)

React with the nicotinic receptor to open the channel and cause depolarisation of the end plate

c)

Cause desensitization, noncompetive block manifested by flaccid paralysis

d)

Cholinesterase inhibitors do not have the ability to reverse the blockade

34.

Which of the following neuromuscular blockers causes transient muscle fasciculations?

a) Mivacurium

b) Pancuronium

c) Succinylcholine

d) Tubocurarine

a)

Mivacurium

b)

Pancuronium

c)

Succinylcholine

d)

Tubocurarine

35.

Indicate muscles, which are more resistant to block and recover more rapidly:

a)

Hand

b)

Leg

c)

Neck

d)

Diaphragm

36.

Which neuromuscular blocking agent has the potential to cause the greatest release of histamine?

a)

Succylcholine

b)

Tubocurarine

c)

Pancuronium

d)

Rocuronium

37.

Which of the following muscular relaxants causes hypotension and bronchospasm?

a)

Vecuronium

b)

Succinylcholine

c)

Tubocurarine

d)

Rapacuronium

38.

Indicate the neuromuscular blocker, which causes tachycardia:

a)

Tubocurarine

b)

Atracurium

c)

Pancuronium

d)

Succinylcholine

39.

Which of the following neuromuscular blocking agents cause cardiac arrhythmias

a)

Vecuronium

b)

Tubocurarine

c)

Rapacuronium

d)

Succinylcholine

40.

Effects seen only with depolarizing blockade include all of the following EXCEPT:

a)

Hypercaliemia

b)

A decrease in intraocular pressure

c)

Emesis

d)

Muscle pain

41.

Which neuromuscular blocking agent is contraindicated in patients with glaucoma

a)

Tubocurarine

b)

Succinylcholine

c)

Pancuronium

d)

Gallamine

42.

Indicate the following neuromuscular blocker, which would be contraindicated in patients with renal failure:

a)

Pipecuronium

b)

Succinylcholine

c)

Atracurium

d)

Rapacuronium

43.

All of the following drugs increase the effects of depolarizing neuromuscular blocking agents EXCEPT

a)

Aminoglycosides

b)

Antiarrhythmic drugs

c)

Nondepolarizing blockers

d)

Local anesthetics

44.

Which of the following diseases can augment the neuromuscular blockade produced by nondepolarizing muscle

relaxants

a)

Myasthenia gravis

b)

Burns

c)

Asthma

d)

Parkinsonism

45.

Indicate the agent, which effectively antagonizes the neuromuscular blockade caused by nondepolarizing drugs:

a)

Atropine

b)

Neostigmine

c)

Acetylcholine

d)

Pralidoxime