WorksheetsAch block
Total questions: 45
Worksheet time: 23mins
Atropine causes:
a) Spasmolitic activity
b) Intestinal hypermotility
c) Stimulation of contraction in the gut
d) Stimulation of secretory activity
Spasmolitic activity
Intestinal hypermotility
Stimulation of contraction in the gut
Stimulation of secretory activity
Which of the following drugs is useful in the treatment of uterine spasms?
Carbachol
Vecuronium
Atropine
Edrophonium
Atropine may cause a rise in body temperature (atropine fever):
In adults
In pregnant women
In infants and children
All of the above
The pharmacologic actions of scopolamine most closely resemble those of:
Hexamethonium
Atropine
Succinylcholine
Pilocarpine
Compared with atropine, scopolamine has all of the following properties EXCEPT:
More marked central effect
Less potent in decreasing bronchial, salivary and sweat gland secretion
More potent in producing mydriasis and cycloplegia
Lower effects on the heart, bronchial muscle and intestines
Which of the following drugs is useful in the treatment of Parkinson′s disease?
Benztropine
Edrophonium
Succinylcholine
Hexamethonium
Indicate the antimuscarinic drug, which is used as a mydriatic:
Pilocarpine
Neostigmine
Homatropine
Ipratropium
Which of the following agents is used as an inhalation drug in asthma?
Atropine
Ipratropium
Lobeline
Homatropine
Which of the following agents is most effective in regenerating cholinesterase associated with skeletal muscle
neuromuscular junctions?
Suscinilcholine
Pralidoxime
Pirenzepine
Propiverine
Indicate an antimuscarinic drug, which is effective in the treatment of mushroom poising:
Pralidoxime
Pilocarpine
Homatropine
Atropine
Antimuscarinics are used in the treatment of the following disorders EXCEPT:
Motion sickness
Glaucoma
Hyperhidrosis
Asthma
The atropine poisoning includes all of the following symptoms EXCEPT:
Mydriasis, cycloplegia
Hyperthermia, dry mouth, hot and flushed skin
Agitation and delirium
Bradicardia, orthostatic hypotension
The treatment of the antimuscarinic effects can be carried out with:
Neostigmine
Hexametonium
Homatropine
Acetylcholine
Contraindications to the use of antimuscarinic drugs are all of the following except:
a) Glaucoma
b) Myasthenia
c) Bronchial asthma
d) Paralytic ileus and atony of the urinary bladder
Glaucoma
Myasthenia
Bronchial asthma
Paralytic ileus and atony of the urinary bladder
Hexamethonium blocks the action of acethylcholine and similar agonists at:
Muscarinic receptor site
Neuromuscular junction
Autonomic ganglia
Axonal transmission
The applications of the ganglion blockers have disappeared because of all of the following reasons EXCEPT:
Orthostatic hypotension
Lack of selectivity
Homeostatic reflexes block
Respiratory depression
Which of the following agents is a short-acting ganglion blocker?
Homatropine
Trimethaphane
Hexamethonium
Pancuronium
Indicate the ganglion-blocking drug, which can be taken orally for the treatment of hypertension?
Mecamylamine
Scopolamine
Trimethaphane
Vecocuronium
The systemic effects of hexamethonium include all of the following EXCEPT
Reduction of both peripheral vascular resistance and venous return
Partial mydriasis and loss of accommodation
Constipation and urinary retention
Stimulation of thermoregulatory sweating
Ganglion blocking drugs are used for the following emergencies EXCEPT:
a) Hypertensive crises
b) Controlled hypotension
c) Cardiovascular collapse
d) Pulmonary edema
Hypertensive crises
Controlled hypotension
Cardiovascular collapse
Pulmonary edema
Agents that produce neuromuscular blockade act by inhibiting
Interaction of acetylcholine with cholinergic receptors
Release of acetylcholine from prejunctional membrane
Packaging of acetylcholine into synaptic vesicles
Reuptake of acetylcholine into the nerve ending
Skeletal muscle relaxation and paralysis can occur from interruption of functions at several sites, including all of the
following EXCEPT
Nicotinic acethylcholine receptors
Muscarinic acethylcholine receptors
The motor end plate
Contractile apparatus
Nondepolarisation neuromuscular blocking agents:
Block acetylcholine reuptake
Prevent access of the transmitter to its receptor and depolarization
Block transmission by an excess of a depolarizing stagoni
All of the above
Which of the following drugs has “double-acetylcholine” structure?
Rocuronium
Carbachol
Atracurium
Succylcholine
Indicate the long-acting neuromuscular blocking agent:
Rapacuronium
Mivacurium
Tubocurarine
Rocuronium
Which of the following neuromuscular blocking drugs is an intermediate-duration muscle relaxant?
Vecuronium
Tubocurarine
Pancuronium
Rapacuronium
Indicate the nondepolarizing agent, which has the fastest onset of effect?
Succinylcholine
Rapacuronium
Pancuronium
Tubocurarine
Indicate the neuromuscular blocker, whose breakdown product readily crosses the blood-brain barrier and may cause
seizures:
Pancuronium
Succinylcholine
Tubocurarine
Atracurium
Which competitive neuromuscular blocking agent could be used in patients with renal failure?
Atracurium
Succinylcholine
Pipecuronium
Doxacurium
Indicate the nondepolarizing agent, which has short duration of action:
Succinylcholine
Tubocurarine
Mivacurium
Pancuronium
Which depolarizing agent has the extremely brief duration of action?
Mivacurium
Rapacuronium
Rocuronium
Succinylcholine
Neuromuscular blockade by both succinylcholine and mivacurium may be prolonged in patients with:
a) Renal failure
b) An abnormal variant of plasma cholinesterase
c) Hepatic disease
d) Both b and c
Renal failure
An abnormal variant of plasma cholinesterase
Hepatic disease
An abnormal variant of plasma cholinesterase
Hepatic disease
Depolarizing agents include all of the following properties EXCEPT:
Interact with nicotinic receptor to compete with acetylcholine without receptor activation
React with the nicotinic receptor to open the channel and cause depolarisation of the end plate
Cause desensitization, noncompetive block manifested by flaccid paralysis
Cholinesterase inhibitors do not have the ability to reverse the blockade
Which of the following neuromuscular blockers causes transient muscle fasciculations?
a) Mivacurium
b) Pancuronium
c) Succinylcholine
d) Tubocurarine
Mivacurium
Pancuronium
Succinylcholine
Tubocurarine
Indicate muscles, which are more resistant to block and recover more rapidly:
Hand
Leg
Neck
Diaphragm
Which neuromuscular blocking agent has the potential to cause the greatest release of histamine?
Succylcholine
Tubocurarine
Pancuronium
Rocuronium
Which of the following muscular relaxants causes hypotension and bronchospasm?
Vecuronium
Succinylcholine
Tubocurarine
Rapacuronium
Indicate the neuromuscular blocker, which causes tachycardia:
Tubocurarine
Atracurium
Pancuronium
Succinylcholine
Which of the following neuromuscular blocking agents cause cardiac arrhythmias
Vecuronium
Tubocurarine
Rapacuronium
Succinylcholine
Effects seen only with depolarizing blockade include all of the following EXCEPT:
Hypercaliemia
A decrease in intraocular pressure
Emesis
Muscle pain
Which neuromuscular blocking agent is contraindicated in patients with glaucoma
Tubocurarine
Succinylcholine
Pancuronium
Gallamine
Indicate the following neuromuscular blocker, which would be contraindicated in patients with renal failure:
Pipecuronium
Succinylcholine
Atracurium
Rapacuronium
All of the following drugs increase the effects of depolarizing neuromuscular blocking agents EXCEPT
Aminoglycosides
Antiarrhythmic drugs
Nondepolarizing blockers
Local anesthetics
Which of the following diseases can augment the neuromuscular blockade produced by nondepolarizing muscle
relaxants
Myasthenia gravis
Burns
Asthma
Parkinsonism
Indicate the agent, which effectively antagonizes the neuromuscular blockade caused by nondepolarizing drugs:
Atropine
Neostigmine
Acetylcholine
Pralidoxime
