WorksheetsWaters HPLC Troubleshooting and Quality Parts Seminar
Total questions: 10
Worksheet time: 3mins
Which of the following are the benefits of Waters Quality Parts?
Waters Quality Parts are tested on Waters system – designed specifically for LC optimal performance
Critical clean process during manufacturing to ensure parts are handled properly – greatly reduces chances of contamination
Peace of mind that the valuable LC investment is protected – system warranty is not invalidated by installing third party parts
All of the above
Which statement is correct?
Waters recommends a Performance Maintenance once every two years
All the critical wear-and-tear components are replaced during the Performance Maintenance regardless of the parts’ conditions
User self-performed maintenance is sufficient to ensure system performance
Quality of the mobile phase will not affect the quality of chromatogram
Which is not correct about the troubleshooting workflow?
Having a system benchmark helps me to have a good chromatogram to refer to when there is a suspected LC problem
I am encouraged to use my own sample to setup as system benchmark
Failure fingerprint should have information on how the chromatogram fails and what causes it to fail
Comparing between failure fingerprint helps me to remove any inconsistent failure causes
What is/are the cause(s) of peak shape problem?
Poor fitting
Column void
Plugged column
Silanol activity from column
All of the Above
QCRM from Waters can be used to? (Choose all the answers that applies)
Benchmark system performance
Perform routine PQ checks
Diagnose/troubleshoot system issues
Tell which parts to change of the system
Under the current USP 621 guideline, which is the chromatographic parameter that can be adjusted without revalidation?
Gradient method
Detector wavelength
Different L listing column
Column length and particle size for isocratic method
Part-part manakah yang kemungkinan besar bermasalah Jika RSD RT tidak masuk (>2%) Pada system HPLC anda?
Solvent Filter, Inlet Filter, Checkvalve dan Seal-seal Plunger
Solvent filter, Needle, needle Seal dan sample Syringe
Inlet Filter, Check Valve, Injector valve dan flowcell detector
Needle Seal, needle, Sample Syringe dan Injector valve
Part-part manakah yang kemungkinan besar bermasalah Jika RSD Area tidak masuk (>2%) Pada system HPLC anda?
Solvent Filter, Inlet Filter, Checkvalve dan Seal-seal Plunger
Solvent filter, Needle, needle Seal dan sample Syringe
Inlet Filter, Check Valve, Injector valve dan flowcell detector
Needle Seals, needle and Sample Syringe
Hal-hal berikut ini dapat menyebabkan peak yang dihasilkan mempunyai nilai tailing yang tinggi, Kecuali?
Interaksi sampel dengan stationary phase dalam kolom
Pemasangan tubing pada kolom tidak sempurna
Kolom terdegradasi/rusak
Sampel menguap
Manakah penyebab yang paling sering kolom mengalami blocking/ mampet?
Algae / Bakteri
Kesalahan memilih filter
Fasa gerak buffer
Semua jawaban benar
