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Molecular basis of inheritance

Total questions: 21

Worksheet time: 21mins

Name
Class
Date
1.

The enzyme DNA dependent RNA polymerase catalyses the polymerisation reaction in ___________direction.

a)

only 5’ → 3’

b)

only 3’ → 5’

c)

both (a) and (b)

d)

none of these

2.

Which of the following types of bacteria were used in Griffith’s transformation experiment?

a)

Diplococcus, R-III and S-II type

b)

Pneumococcus, T2 phage

c)

Streptococcus, R-II and S-III type

d)

Diplococcus, E. coli

3.

THE EQUIVALENT OF STRUCTURAL GENE IS

a)

MUTON

b)

CISTRON

c)

OPERON

d)

RECON

4.

Which of the following is required as inducer for the expression of lac operon?

a)

Lactose

b)

Galactose and Lactose

c)

Glucose

d)

Galactose

5.

ASSERTION-The nitrogenous base of two chains of DNA are held together by hydrogen bonds


Reason-Both chains of DNA are antiparallel

a)

If both Assertion and Reason are true and reason is correct explanation of Assertion

b)

If both Assertion and Reason are true but reason is not correct explanation of Assertion

c)

Assertion is true reason is false

d)

Both Assertion and Reason are false

6.

Regulation of gene expression occurs at the level of

a)

transcription

b)

processing/splicing

c)

translation

d)

all of these.

7.

Based on the experiments by Hershey and Chase, which of the following statements are true? (Choose all the correct answers)

a)

(i) They conducted their experiment on the fact that DNA contains phosphorous.

b)

(ii) They conducted their experiments on the fact that proteins contain phosphorous.

c)

(iii) They incorporated radioactive isotope of phosphorous into bacteriophage.

d)

(iv) They showed that when P32 was used all radioactivity was associated with bacterial cells

e)

(v) The isotopes P32 and S35 were used independantly to infect the bacterium E coli

8.

What are those structures that appear as ‘beads-on-string’ in the chromosomes when viewed under electron microscope?

a)

Base pairs

b)

Genes

c)

Nucleotides

d)

Nucleosomes

9.

Which of the following is not the characteristic feature of genetic code

a)

Triplet nature

b)

Mostly universal

c)

Ambiguous

d)

Degeneracy

10.

In a virus, the percentage of thymine was 21%, adenine 32%, cytosine 23% and guanine 24% in its genetic material. The nature of genetic material present in this virus is

a)

ds DNA

b)

ss DNA

c)

ss RNA

d)

ds RNA

11.

The bioactive substance which removes clots from blood vessels is

a)

Butyric acid

b)

Cyclosporin A

c)

Statins

d)

Streptokinase

12.

Bacillus thuringiensis is used as biocontrol agent against

a)

Mosquitoes

b)

Aphids

c)

Pathogenic fungi

d)

Butterfly caterpillars

13.

In a 3.2 Kbp long piece of DNA, 820 adenine bases were found. What would be the number of cytosine bases?

a)

780

b)

1560

c)

740

d)

1480

14.

Escherichia coli with completely radioactive DNA was allowed to replicate in nonradioactive medium for two generations. Percentage of bacteria with radioactive DNA is

a)

12.5%

b)

25%

c)

50%

d)

100%

15.

Select the correct option from the following :

a)

(A)-(iii), (B)-(ii), (C)-(i)

b)

(A)-(i), (B)-(iii), (C)-(ii)

c)

(A)-(i), (B)-(ii), (C)-(iii)

d)

(A)-(ii), (B)-(iii), (C)-(i)

16.

To make protein with 178 amino acid from eukaryotic gene having 1350 bp, the length of initial and processed mRNA transcript would respectively be

a)

640 b, 52 b

b)

1350 b, 1350 b

c)

1350 b, 537 b

d)

670 b, 540 b

17.

If there are 999 bases in an RNA that codes for a protein with 333 amino acids, and the base at position 901 is deleted such that the length of the RNA becomes 998 bases, how many codons will be altered ?

a)

11

b)

33

c)

333

d)

1

18.

What will be the sequence of mRNA produced by the following stretch of DNA?

3' ATGCATGCATGCATG 5' TEMPLATE STRAND

5' TACGTACGTACGTAC 3' CODING STRAND

a)

3' AUGCAUGCAUGCAUG 3'

b)

3' AUGCAUGCAUGCAUG 5'

c)

5' UACGUACGUACGUAC 3'

d)

3' UACGUACGUACGUAC 5'

19.

If the distance between two consecutive base pairs is 0.34nm and the total number of base pairs of a DNA double helix in a typical mammalian cell is  6.6×1096.6\times10^9  base pair , then the length of the DNA is approximately

a)

2.2 meters

b)

2.5 meters

c)

2.7 meters

d)

2.0 meters

20.

Read the following four statements (A-D):

(A) In transcription, adenosine pairs with uracil.

(B) Regulation of lac operon by repressor is referred to as positive regulation.

(C) The human genome has approximately 50,000 genes.

(D) Haemophilia is a sex-linked recessive disease.

How many of the above statements are right ?

a)

Two

b)

Three

c)

Four

d)

One

21.

The correct match is

a)

I – D, II – B, III – A, IV – C

b)

I – B, II – A, III – D, IV – C

c)

I – D, II – C, III – A, IV – B

d)

I – B, II – C, III – A, IV – D