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Oct Tremfya 1 QUIZ 2025

Total questions: 47

Worksheet time: 22mins

Name
Class
Date
1.

Withdrawal-retreatment concept for GUS was tested in ............ trial

a)

DISCOVER 1

b)

DISCOVER 2

c)

VOYAGE 1

d)

VOYAGE 2

2.

RIZA is approved in

a)

CD

b)

UC

c)

PsA

d)

PSO

e)

AD

3.

GUS must be used with MTX in PsA while TOFA can be used alone

a)

True

b)

False, Both must with MTX

c)

False, Both mono

d)

False, GUS mono but TOFA must be with MTX

4.

.......% of PsA has sub clinical IBD

a)

70-80

b)

10-20

c)

30-40

d)

50-60

5.

100 patients at W0, 70 Patients at W52, only 35 in response, response rate NRI is..... while AO is......

a)

50,35

b)

35,35

c)

35,50

d)

50,50

6.

Safety results at w52 DISCOVER 2 reported

a)


No IBD, No OI, No TB

b)

IBD reported

c)

TB reported

d)

OI reported

7.

PROMIS score domains include "Select all"

a)

Fatigue

b)

Anxiety

c)

Pain

d)

Sleep

e)

Enthesitis

8.

When Dr is challenging the axial efficacy of GUS, you can present (Select all that apply)

a)

DISCOVER primary EP

b)

ASAS 20

c)

mBASDAI

d)

ASDAS

e)

ASAS 40

9.

Patients with Axial involved in DISCOVER 1&2 were having "Select all"

a)

No imaging history

b)

IBP

c)

Imaging confirmed SI

d)

History confirming SI

10.

In DISCOVER program, ACR 20 was SIG as fast as week

a)

8

b)

4

c)

16

d)

24

11.

SEC is approved in "Select all"

a)

Axial SpA

b)

PsA

c)

Uveitis

d)

RA

e)

PSO

12.

Can GUS used with MTX?

a)

No

b)

Yes

13.

Biologics approved in PsA "Select all"

a)

IFX

b)

SEC

c)

GUS

d)

UPA

e)

UST

14.

PsA MDA score has

a)

3

b)

4

c)

5

d)

6

e)

7

15.

What is primary EP for ECLIPSE trail and what was the result?

a)

PASI90 W12, 70%

b)

PASI90 W24, 84%

c)

PASI90 W48, 84%

d)

PASI90 W48, 70%

16.

ECLIPSE trial was ...................... trial type VS.................

a)

Inferior, SEC

b)

Superior, SEC

c)

Superior, ADA

d)

Inferior, ADA

17.

What was the EP for regional PSO in VOYAGE 2 that was not superior for GUS VS ADA?

4 lines
18.

How many patients had IBD in ECLIPSE? Which arm?

a)

none

b)

5 in SEC arm

c)

3 in SEC arm

d)

5 in GUS arm

e)

3 in both arms

19.

Out of 10? How many patients were PASI 100 from at week 256?

a)

2

b)

5

c)

7

d)

0

e)

9

20.

GUS is effective for patients with Mets?

a)

Yes but more adverse events

b)

NO

c)

Yes with the same safety profile

d)

Only effective for PSO without Mets

21.

For which regional psoriasis measures was Guselkumab superior to placebo and/or adalimumab in VOYAGE-1?

a)

Scalp, nails, and hands and feet

b)

Scalp, and hands and feet

c)

Hands and feet only

d)

Nails only

22.

Pain is included in PROMIS-29?

a)

Yes

b)

No

23.

Grade 4 hematological abnormalities were reported with GUS for PsA?

a)

Yes and led to discontinuation

b)

No

c)

Yes but did not lead to discontinuation

24.

VDH score was modified in PsA to include

a)

Feet joints

b)

Wrist joints

c)

PIP joints

d)

DIP joints

25.

m-VDH score is used to assess "Select all"

a)

Peripheral joints

b)

Axial disease

c)

JSN

d)

Spine changes

e)

Joint erosion

26.

Riza approved doing in PsA is same as PSO?

a)

Yes

b)

No, not approved

c)

No, has additional every 2 month dose

27.

DISCOVER 2 primary EP was.....at week....... and was.............

a)

ACR50, W12, 40%

b)

ACR20, W24, 60%

c)

ACR20, W12, 60%

d)

ACR20, W16, 40%

e)

ACR20, W16, 60%

28.

....% can have sole axial PsA?

a)

20

b)

10

c)

5

d)

50

29.

Radiographic progression was significant VS Placebo with both GUS dosing in DISCOVER 2?

a)

True

b)

NO, Only q8w

c)

No, only q4w

d)

Neither

30.

In PsA GUS should be asses after....weeks while in PSO after......weeks

a)

16,24

b)

24,24

c)

24,16

d)

16,16

31.

MDA domains include "Select any"

a)

TJC

b)

SJC

c)

enthsitis

d)

PASI

e)

Pain

32.

.......% completed 2 years GUS PsA

a)

50

b)

60

c)

75

d)

90

33.

Tb was reported in DISCOVER 2 years data?

a)

No

b)

Yes, only 1 case

c)

Yes but non significant

34.

Riza can be given without TB test?

a)

Yes

b)

No

35.

mBASDAI removed question ....related to.........involvement

a)

2, axial

b)

2, peripheral

c)

3, axial

d)

3, peripheral

e)

None was removed

36.

GUS pooled data for axial PsA reported ASDAS impact?

a)

Yes

b)

No as it is for AS only

37.

In GRAPPA 2022, GUS has not sufficient evidence in........domain

a)

IBD

b)

Uveitis

c)

Nail

d)

Enthesitis

e)

Axial PsA

38.

Anxiety & Depression data were reported in

a)

VOYAGE 1

b)

VOYAGE 2

c)

DISCOVER 1

d)

DISCOVER 2

e)

None

39.

Anxiety & depression were reported in DISCOVE 1?

a)

Yes

b)

No

40.

SEC dosing in PSO in HIO protocol is

a)

150mg with loading

b)

300mg with loading

c)

150mg without loading

d)

300mg without loading

41.

SEC doing in HIO for PsA is

a)

150mg with loading

b)

150mg without loading

c)

300mg with loading

d)

300mg without loading

42.

GUS is the only fully human IL23i approved in PSO & PsA?

a)

No, Riza is

b)

No, Tildra is

c)

Yes

43.

Which data reported by GUS in PsA and not by RIZA? "Select any"

a)

Enthesitis

b)

Dactylitis

c)

Peripheral

d)

Axial

e)

Radiographic

44.

Which RCT address genital\Facial PSO with GUS?

a)

SPECTRUM

b)

VISIBLE

c)

GULLIVER

d)

G-EPOSE

45.

Which trial address Skin of color for GUS PSO patients?

a)

GULLIVER

b)

VISIBLE

c)

APEX

d)

SPECTRUM

46.

Which GUS trial has a specific Scalp PSO group?

a)

SPECTRUM

b)

ECLIPSE

c)

VOYAGE 2

d)

VISIBLE

47.

Which Trail demonstrated efficacy of GUS Q8W in inhibiting radiographic progression at W24?

a)

DISCOVER 1

b)

DISCOVER 2

c)

APEX

d)

COSMOS

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