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Autoimmunity

Total questions: 23

Worksheet time: 14mins

Name
Class
Date
1.

The following antibodies are subtypes of anti-phospholipid Ab found in SLE that could lead to anti-phospholipid syndrome (hypercoagulation state)

a)

Anti-Sm

b)

Anti-cardiolipin

c)

Anti-B2-glycoprotein

d)

Anti-dsDNA

2.

2 types of hypersensitivity reactions are involved in SLE?

a)

Type 1

b)

Type 2

c)

Type 3

d)

Type 4

3.

Allelic predisposition for the development of SLE include: (Choose 2)

a)

HLAB27

b)

HLA-DR2

c)

HLAB57

d)

HLA-DR3

4.

True or False: Deficiency of complement are though to be the initial precursor for the development of SLE?

a)

True: Deficiencies of C1q, C2, and C3

b)

True: Deficiencies of C4d

c)

False: Ab against immune complexes are the precursor

d)

False: Error in central tolerance is the precursor.

5.

Skin manifestation of SLE include various rashes, this are: (Select 3)

a)

Malar

b)

Maculopapular

c)

Discoid

d)

Raynoud

6.

T/F: ANA antibodies have a greater specificity for SLE than anti-dsDNA and anti-SM

a)

True

b)

False

7.

The following drug can be used in the treatment of Lupus

a)

Procainamide

b)

Isoniazid

c)

Minocycline

d)

Hydroxycloroquinone

8.
a)

Anti-ssDNA

b)

ANA

c)

Anti-SM

d)

Anti-cardiolipin

9.

Patients with Sjogren syndrome are at risk for

a)

Hodgkin Lymphoma

b)

Non-Hodgkin Lymphoma

c)

Lofgren syndrome

d)

Segmental glomerulosclerosis

10.

Sicca syndrome is a combination of (select 2)

a)

Xerophtalmia

b)

Keratoconjuctivitis

c)

Xerostomia

d)

Dyspaneuria

11.

Which antibody will be diagnostic of the patient's conditions

a)

Anti-dsDNA

b)

Anti-SM

c)

ANA's

d)

Anti-Ro/La

12.

Mutations in which transcription factor will lead to IPEX: Immune Disregultion Polyendocrinopathy Enteropathy X-linked

a)

NFAT

b)

NF-KB

c)

FOXP3

d)

STAT3

13.

Negative selection of T cells (due to self-reactivity) may lead to apoptosis through which mechanism? (Select 2)

a)

BIM

b)

FAS:FASL

c)

MAC Complex

d)

ERK:1/2

14.

Neoantigens involved in the pathogenesis of RA arise from which proteins? More than 1 answer is correct

a)

Argenin deiminase

b)

Fillagrin

c)

Vimentin

d)

Citrullin

15.

Reumatoid factor is defined as (More than 1 is correct)

a)

IgE-anti-Fc-IgG

b)

IgA-anti-Fc-IgG

c)

IgM-anti-Fc-IgG

d)

IgA-anti-Fab-IgG

16.

Anti-citrullinated peptide-Antibodies are diagnostic for?

a)

Dermatomyositis

b)

SLE

c)

SJOGREN

d)

Reumatoid Artheritis

17.

T/F: IgA Rheumatoid Factor is more specific than IgM Rheumatoid Factor for RA

a)

True

b)

False

18.

A patient complains about a dry mouth, eyes, and vagina. You as a physician immediately think of?

a)

Ab-against goblet cells

b)

SJOGREN

c)

Destruction of acini due to complex deposition in SLE

19.

These are viruses associated with the development of SJOGREN. More than one is correct

a)

Hep C

b)

HIV

c)

EBV

d)

HTLV

20.

Anti-Mi-2 / Anti-Jo1 / Anti-P155 are diagnostic for?

a)

Sclerosis

b)

Dermatomyositis

c)

Contact Dermatitis

d)

Subtype of SLE against helicase

21.

Patient presents with hyperpigmentation of the neck and nuckles. Vasculitis is discovered upon examination. This presentation would be characteristic of?

a)

Polyarthritis nodosa

b)

Dermatomyosis

c)

SJOGREN

d)

Systemic Sclerosis

22.

Patients presents with heliotrope rash + proximal muscle weakness, possible diagnosis is?

a)

Systemic Sclerosis

b)

SLE

c)

Dermatoyositis

23.

Loss of internal elastic layer of blood vessels

a)

Sclerosis / Scleroderma

b)

Polyartheritis nodosa