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WorksheetsAutoimmunity
Total questions: 23
Worksheet time: 14mins
The following antibodies are subtypes of anti-phospholipid Ab found in SLE that could lead to anti-phospholipid syndrome (hypercoagulation state)
Anti-Sm
Anti-cardiolipin
Anti-B2-glycoprotein
Anti-dsDNA
2 types of hypersensitivity reactions are involved in SLE?
Type 1
Type 2
Type 3
Type 4
Allelic predisposition for the development of SLE include: (Choose 2)
HLAB27
HLA-DR2
HLAB57
HLA-DR3
True or False: Deficiency of complement are though to be the initial precursor for the development of SLE?
True: Deficiencies of C1q, C2, and C3
True: Deficiencies of C4d
False: Ab against immune complexes are the precursor
False: Error in central tolerance is the precursor.
Skin manifestation of SLE include various rashes, this are: (Select 3)
Malar
Maculopapular
Discoid
Raynoud
T/F: ANA antibodies have a greater specificity for SLE than anti-dsDNA and anti-SM
True
False
The following drug can be used in the treatment of Lupus
Procainamide
Isoniazid
Minocycline
Hydroxycloroquinone
Anti-ssDNA
ANA
Anti-SM
Anti-cardiolipin
Patients with Sjogren syndrome are at risk for
Hodgkin Lymphoma
Non-Hodgkin Lymphoma
Lofgren syndrome
Segmental glomerulosclerosis
Sicca syndrome is a combination of (select 2)
Xerophtalmia
Keratoconjuctivitis
Xerostomia
Dyspaneuria
Which antibody will be diagnostic of the patient's conditions
Anti-dsDNA
Anti-SM
ANA's
Anti-Ro/La
Mutations in which transcription factor will lead to IPEX: Immune Disregultion Polyendocrinopathy Enteropathy X-linked
NFAT
NF-KB
FOXP3
STAT3
Negative selection of T cells (due to self-reactivity) may lead to apoptosis through which mechanism? (Select 2)
BIM
FAS:FASL
MAC Complex
ERK:1/2
Neoantigens involved in the pathogenesis of RA arise from which proteins? More than 1 answer is correct
Argenin deiminase
Fillagrin
Vimentin
Citrullin
Reumatoid factor is defined as (More than 1 is correct)
IgE-anti-Fc-IgG
IgA-anti-Fc-IgG
IgM-anti-Fc-IgG
IgA-anti-Fab-IgG
Anti-citrullinated peptide-Antibodies are diagnostic for?
Dermatomyositis
SLE
SJOGREN
Reumatoid Artheritis
T/F: IgA Rheumatoid Factor is more specific than IgM Rheumatoid Factor for RA
True
False
A patient complains about a dry mouth, eyes, and vagina. You as a physician immediately think of?
Ab-against goblet cells
SJOGREN
Destruction of acini due to complex deposition in SLE
These are viruses associated with the development of SJOGREN. More than one is correct
Hep C
HIV
EBV
HTLV
Anti-Mi-2 / Anti-Jo1 / Anti-P155 are diagnostic for?
Sclerosis
Dermatomyositis
Contact Dermatitis
Subtype of SLE against helicase
Patient presents with hyperpigmentation of the neck and nuckles. Vasculitis is discovered upon examination. This presentation would be characteristic of?
Polyarthritis nodosa
Dermatomyosis
SJOGREN
Systemic Sclerosis
Patients presents with heliotrope rash + proximal muscle weakness, possible diagnosis is?
Systemic Sclerosis
SLE
Dermatoyositis
Loss of internal elastic layer of blood vessels
Sclerosis / Scleroderma
Polyartheritis nodosa
