WorksheetsHematology Platings- Prelims
Total questions: 45
Worksheet time: 23mins
False about Myeloid period of hematopoiesis:
There is a gradual increase of Hgb A1 in the later part of the 3rd trimester
Usually begins approximately between the 4th and 5th week of pregnancy
Both A and B
Neither A nor B
Embryonic molecular globin chains include:
zeta
beta
Both A and B
Neither A nor B
Which of the following is True about prorubricyte?
It usually divides twice thus producing 4 rubricyte.
Late stage of it may exhibit 1:1 ratio with murky grayish-red-blue cytoplasm
Both A and B
Neither A nor B
False about erythropoietin (EPO):
It is a glycolipids with a molecular weight of 34 Daltons
it influences differentiation of immature red cells by activation of “STAT “pathway
Both A and B
Neither A nor B
This/ese immature red cell/s is/are capable of synthesizing Hgb?
Rubriblast
Metarubricyte
Both A and B
Neither A nor B
True about the immediate precursor cell of rubricyte:
Has a basophilic cytoplasmic appearance
Has a 6:1 N:C ratio
Both A and B
Neither A nor B
Which of the statement/s is/are incorrect?
The HSC may randomly retain as stem cell for storage pool according to instructive model.
The asymmetric division of HSC’s is characterized by one for renewal and one for differentiation.
Both A and B
Neither A nor B
False about polychromatophilic erythrocyte:
It usually stays approximately in the bone marrow for 48 hours
With highly compact chromatin materials.
Both A and B
Neither A nor B
The Hematopoietic stem cells (HSC) is activated by internal stimulators such as:
KIT-Ligand and NOTCH 2
GATA 2 genes and FLT3-Ligand
Both A and B
Neither A nor B
Which of the following statement is False?
Pyrenocyte is characterized by a red cell with extruded nuclear material.
The metarubricyte is the last progenitor red cell incapable of Hgb synthesis
Both A and B
Neither A nor B
Which of the following growth factors are needed for the maturation of the progenitor cell for red cell production?
TPO and IL-3
CSF-Meg and IL-11
Both A and B
Neither A nor B
True about polychromatophilic erythroblast:
Commonly has 1:2 N:C ratio
The most mature progenitor red cell with nucleus.
Both A and B
Neither A nor B
False about mesoblastic period of hematopoiesis:
Usually begins on the 19th-20th week of pregnancy
Commonly ends before the 2nd month of pregnancy
Both A and B
Neither A nor B
True about Hepatic Period of hematopoiesis:
The predominating type of Hgb produced is Hgb A1
The peak of blood production by the liver occurs during between 6th to 7th month of gestation
Both A and B
Neither A nor B
True about Hepatic period of hematopoiesis:
The majority of hgb type synthesized is Hgb F
There is a gradual increase of Hgb A1 concentration between 4th to 5th month of gestation
Both A and B
Neither A nor B
Which of the following sites may be used for core biopsy examination of bone marrow?
A. Posterior Superior Iliac crest
B. Sternum
C. Tibia
After a failed first marrow collection, what should be the next action of the attending physician?
Stop the procedure and advice the patient to rest and set another schedule for marrow collection
Report it as a dry tap
Stop the procedure and go to another site
Try another collection by returning the obturator and attaching a fresh syringe
A false decrease/absence of iron in bone marrow core biopsy is attributed to:
Decalcification process
Use of anticoagulant
Fixation of specimen
An additional cytochemical studies in a bone marrow specimen is useful for the diagnosis of:
A. Leukemia
B. Lymphoma
C. Point mutations
A and B
A, B, C
It is the site for T-cell maturation:
Lymph nodes
Spleen
Bone marrow
Liver
Thymus
True with bone marrow examination:
I. Invasive procedure
II. Used to diagnose and stage Non-Hematologic neoplasia
III. Used to confirm or exclude metabolic or infectious conditions
IV. Recommended for patients with coagulopathies
I and II
I and IV
I, II, III
I, II, IV
I, II, III, IV
True with liver:
I. capable of producing blood cells
II. contains macrophages that remove old cells and foreign debris
III. increases conjugation of bilirubin during hemolytic anemia
IV. serves as iron storage area
I and III
I, II, III
I, III, IV
I, II, III, IV
A bone marrow examination result may include:
I. BM differential count
II. CBC
III. Flow Cytometry Analysis
IV. Cellularity
I and II
I and IV
I, II, III
I, II, IV
I, II, III, IV
Primary lymphoid organs include:
A. Bone marrow
B. Thymus
C. Liver
A and B
A, B, C
To reduce the occurrence of basket cells, this substance is mixed with marrow specimen:
EDTA
Albumin
Citrate
Lidocaine
A core biopsy is preferred over aspirate marrow specimen because:
A. it represents all cells
B. it explains a dry tap
C. it is used for cell differentials
A and B
A, B, C
After the aspiration of the ME layer in a centrifuged marrow specimen, a smear is prepared by:
A. Crush Smear Technique
B. Touch Preparation
C. Direct Smear
A and B
B and C
Arrange the following from the least to most number in a normal bone marrow specimen:
I. Lymphocytes II. Basophils III. Neutrophilic bands IV. Rubricytes
I-II-III-IV
II-IV-I-III
I-IV-II-III
II-I-IV-III
A dry tap may be seen in:
I. fibrotic marrow
II. acellular marrow
III. marrow packed with leukemic cells
IV. improper sampling
IV only
I and II
II and IV
II, III, IV
I, II, III, IV
Which of the following are examined under low power magnification?
I. estimation of marrow cellularity
II. selection of the appropriate site prior to differential count
III. computation of M:E ratio
IV. estimation of megakaryocytes
I and II
I and IV
I, II, III
I, II, IV
I, II, III, IV
Deficiency of this/ese protein/s may cause spherocytic formation of red cells
protein band 4.1
protein band 3
Both A and B
Neither A nor B
Which will cause the O2 curve to the right?
high 2,3DPG
Presence of Hgb F
Both A and B
Neither A nor B
Enzyme that is part of the EMP of red cell metabolism:
Glucose 6 Phosphate dehydrogenase
Pyruvate kinase
Both A and B
Neither A nor B
Which of this increases the binding of oxygen molecule to the HGB?
high 2,3 DPG level
Methemoglobin formation
Both A and B
Neither A nor B
The 2,3, DPG is synthesized specifically at:
Rapaport-Luebering pathway
Hexose Monophosphate pathway
Both A and B
Neither A nor B
Which will cause O2 curve to the left?
Hgb F
carboxyhgb
Both A and B
Neither A nor B
Function of the HMP:
Prevents peroxides formation within Hgb molecule
maintenance of oxidized glutathione
Both A and B
Neither A nor B
Normally 100% O2 saturation of HGB occurs at what oxygen pressure?
30 mmHg
80 mmHg
Both A and B
Neither A nor B
Which of this cause shift to the left of oxygen dissociation curve?
Hypoxia
Hypoventilation
Both A and B
Neither A nor B
Will cause a shift to the Right on oxygen dissociation curve:
Low blood pH
Hypothermia
Both A and B
Neither A nor B
Haldane effect is:
Relative binding of CO2 to unoxygenated Hgb and oxygenated Hgb
It is the process that prevents the rebinding of CO2 to the Hgb within the lung tissue.
Both A and B
Neither A nor B
False about Bohr effect:
It is a reaction that helps maintaining blood pH normal
It is reaction that will dictate the oxygen and Hydrogen binding to the HGB molecule.
Both A and B
Neither A nor B
p50 or 50% oxygenation of Hgb normally occurs when the partial pressure of O2 reaches:
21 mmHg
27 mmHg
Both A and B
Neither A nor B
Which is False?
PNH is a condition where there is a deficiency of GPI-linked RBC membrane protein.
Hereditary spherocytosis is caused by deficiency of protein band 4.1
Both A and B
Neither A nor B
Enzyme involved in the primary or 1st phase of glucoe metabolism under the EMP pathway
Pyruvate kinase
Lactate dehydrogenase
Both A and B
Neither A nor B
