Affected vessel: Large

Location: Arteries from aortic arch (branch points)

Clues: Weak pulse, neurological symptoms, and difficulty to raise the arms.

Labs: ⬆ ERS

Pathology:

Affected vessel: Medium

Location: Coronary arteries serving heart

Clues: Boy <4 y/o, fever at least for 5 days, conjuctivitis, polymorphic exanthem, fingertip desquamation, lymphadenopathy, and edema in palm and soles.

Labs: ⬆ ERS and ⬆ CRP

Affected vessel: Medium

Location: Skin, GI tract and Kidney.

Clues: Associated with HBV and HBsAg complexes, Hypertension, Chronic renal failure, rash, ulcerations and nodules, and polyneuropathy.

Labs: ⬆ ERS and (-) ANCA

Affected vessel: Medium

Location: Blood clots in small arteries of fingers and toes.

Clues: Young male, Polyphenols antibodies, inflammation and thrombosis of superficial veins, intermittent claudication, ischemia, gangrene, and Raynaud phenomenom.

Affected vessel: Small

Location: Nasopharynx, lugs, kidneys.

Clues: chronic sinusitis, saddle nose deformity, ulcers, cavitations, hemoptysis, ⬇ urine and ⬆ BP.

Diagnosis: (+) PR3-ANCA

Affected vessel: Small

Location: Lungs, skin ,and kidneys.

Clues: Kidney inflammation, weight loss, skin lesions, nerve damage, palpable purpura nodule, necrosis, hemoptysis, pauci-immune glomerunephritis.

Diagnosis: (+) MPO-ANCA/pANCA

Affected vessel: Small

Location: Lungs, CNS, heart, and kidneys.

Clues: Sinusitis, lung damage, asthma, eosinophilia, skin nodules, allergic rhinitis,

Diagnosis: (+) MPO-ANCA/pANCA and ⬆ IgE

Affected vessel: All vessels

Associated with HLA-B51.

Clues: Oral aphthous ulcers, genital ulcers, uveitis, skin papules, vision loss, headaches, disorientation and stroke. Swollen joints.