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WorksheetsNucleus Histology
Total questions: 21
Worksheet time: 11mins
You are investigating maternal factors that regulate the
cell cycle during early development. A mouse embryo is
flushed from the uterine tube, treated with acid Tyrode
solution to remove its zona pellucida, and examined by
phase microscopy (shown in the image). The embryo
exhibits a cleavage furrow and appears to be undergoing
cytokinesis. These events take place during what phase
of mitosis?
Anaphase
Interphase
Metaphase
Prophase
Telophase
A digital slide of a sympathetic chain ganglion is examined
in the histology laboratory. Large multipolar neurons
are surrounded by nerve fibers and connective
tissue (shown in the image). Identify the dark basophilic
region within the nucleus of these ganglion cells.
Basal body
Centrosome
Golgi apparatus
Nucleolus
Peroxisome
A kidney biopsy from a 44-year-old man is examined
by electron microscopy. The nucleus of an endothelial
cell exhibits a peripheral ring of dark-stained chromatin
(arrow, shown in the image). Which of the following best
describes the functional significance of the dark-stained
ring of marginal chromatin observed in this electron
micrograph?
DNA replication center
Kinetochore complex assembly
Nucleosome assembly
Organization of inactive chromatin
Ribosomal RNA biosynthesis
Which of the following proteins contributes to the structural
matrix that anchors chromatin to the nuclear membrane
during interphase of the cell cycle?
Desmin
Keratin
Lamin
Perlecan
Vimentin
As part of your research, you investigate the role of
cyclins and cyclin-dependent kinases in regulating ES
cell growth in vitro. These rapidly dividing cells spend
most of their time in which phase of the mitotic cell
cycle?
G0
G1
G2
M
S
Cell cycle wherein whole chromosomes move in Anaphase I
Meiosis I
Meiosis 2
G1 Phase
Interphase
Cell cycle wherein somatic cells are involved with only 1 division present and occurs throughout life
(a)
Specific phase in Prophase I of meiosis wherein there will be exchange of genetic material between homologous chromosomes
Zygotene
Diplotene
Pachytene
Leptotene
The phase between two successive divisions and normally equals to 90% of the total cell cycle time
(a)
The phase wherein the chromosomes are at opposite poles and the centromere are aligned with chromatids attached to the microtubules
(a)
Phase wherein the chromosome separate and sister chromatids are liberated and chromosomes move to the opposite side
(a)
The phase where division of the cytoplasm begins during cell division
(a)
The cleavage furrow is formed during
(a)
Terminal phase of the cell cycle
(a)
A contractile ring and cytokinesis are seen during
(a)
Kinetochores are located
(a)
What pulls the chromosomes apart during mitosis?
(a)
Which cell differentiates directly into spermatozoa:
(a)
Term used when the cells begin to fragment and DNA broken down to small pieces
Pyknosis
Karyorrhexis
Karyolysis
Normal cell
Nuclear condensation
Pyknosis
Karyorrhexis
Karyolysis
Type of cell death – damage to cell membranes, mitochondrial swelling, cytoplasmic swelling, leakage of cellular contents with complement activation and inflammatory response
Apoptosis
Degradation of Cell membrane
Dehydration of Cell
Necrosis
