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WorksheetsALCIPRO
Total questions: 10
Worksheet time: 10mins
MOA of Ciprofloxacin
Inhibition of DNA Gyrase
inhibition of
topoisomerase -4
breaking cell wall synthesis
breaking protein synthesis
There are no bacterial resistance for Alcipro.
complete blockage of DNA gyrase has no possibility of plasmid mediated resistance.
fastest bactericidal action does not allow resistance to occur thus even chromosomally mediated resistance is unlikely (chances being 1 in billion).
synthetic compound, is not susceptible to degradation by any known bacterial enzyme e.g. beta-lactamases
MIC value of Alcipro is
0.01-2 mg/ litre
.01-2 mcg/ml.
.02-1 mg/litre
.02-1 mcg/ml.
Alcipro covers following Aerobic Gram-positive Microorganisms
•Enterococcus faecalis
•Staphylococcus aureus
•Staphylococcus epidermidis.
•Staphylococcus saprophyticus.
•Streptococcus pneumoniae.
Alcipro Covers Aerobic Gram-negative Microorganisms
•Citrobacter freundii.
•Escherichia coli.
•Haemophiles influenzae.
•Klebsiella pneumoniae.
•Moraxella catarrhalis
•Alcipro Covers Aerobic Gram-negative Microorganisms
•Neisseria gonorrhoeae
•Pseudomonas aeruginosa
•Shigella dysenteriae
•Salmonella typhi
Alcipro does not cross-react with other -------------- such as beta-lactams or aminoglycosides
(a)
Match the following PK for Alcipro
69-85%
Bioavailability
20-40%
Protein Plasma Binding
.01-2 Mcg/Ml
MIC
4 Hrs
half -life
10-12 hrs
Therapeutic levels
Match the following Dosing for Oral Alcipro
250 mg/ BID
Gastroenteritis
500mg/ BID
enteric fever
250 mg stat
gonorrhea
1.5 gms
Maximum Daily dose
500-700 mg
septicemia/ bacteremia
Match the following Dosages of Alcipro intravenous therapy
100mg, slow IV fusion
upper & lower UTI
200mg/ bid
LRTI
100 mg/ OD
gonorrhea
200mg / 100 ml vial
surgical infections/ prophylaxix
