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Worksheets12U3 L9 mutations
Total questions: 10
Worksheet time: 9mins
What is a mutation?
A change in a DNA base sequence
A change in an RNA codon sequence
A change in an amino acid sequence
A change in the tertiary shape of a protein
What type of mutation involves one base being exchanged for another?
Substitution
Deletion
Insertion
Frame shift
Which of the following shows a substitution mutation during replication of the sequence AAT GCC AGA?
TTA CCG TCT
TTA CGG TCT
TTA CGG TC
TTA CGG TTC T
A substitution mutation occurs on the DNA sequence AGG, changing the triplet to AGA. What effect does this have on the final protein?
No effect, both triplets code for serine
No effect, both triplets code for arginine
The protein will contain arginine instead of serine
The protein will contain serine instead of arginine
Why are substitution mutations least likely to have an effect on the final protein?
Because different codons can encode the same amino acid
Because different codons encode different amino acids
Because each amino acid has its own unique codon
Because the genetic code is universal
Which type(s) of mutations cause frame-shift?
Deletion
Insertion
Substitution
Point
What is frame-shift?
When every codon that follows a mutation is altered
When a single codon is altered by a mutation
When a mutation affects the sequence of amino acids in a protein
When a mutation affected the final tertiary structure of a protein
What is not an effect of a mis-sense mutation?
A codon encodes a different amino acid
A codon becomes a stop codon and does not encode an amino acid
One or more of the bases in a codon is altered
All subsequent codon sequences are altered (frame shift)
What is the term used to describe a substitution mutation that turns a coding sequence into a stop codon?
(a)
A substitution mutation occurs on the DNA sequence that changes the mRNA codon CCG to CGG. How can this mutation be described?
Mis-sense
Non-sense
Silent
