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Biosynthesis of Nucleic Acids

Total questions: 8

Worksheet time: 5mins

Name
Class
Date
1.

The first enzyme which regulates pyrimidine de novo synthesis is

a)

Carbamoyl phosphate

b)

OMP decarboxylase

c)

Carbamoyl phosphate synthetase II

d)

Aspartate transcarbamoylase

2.

Thymidylate synthase is involved in producing RNA nucleotide

a)

True

b)

False

3.

In pyrimidine salvage pathway, nucleoside kinase catalyses production of nucleotides

a)

True

b)

False

4.

De novo synthesis of purines differs from pyrimidine by the involvement of

a)

Glutamate

b)

Aspartate

c)

Glycine

5.

In the presence of aspartate, IMP will favor production of

a)

OMP

b)

AMP

c)

GMP

d)

UMP

6.

Lack of HGPRT may increase level of purine bases

a)

True

b)

False

7.

In pyrimidine degradation, thymine--> dihydrothymine --> N-carbamoyl-B-alanine --> X --> Acetyl-coA. What is X?

a)

B-alanine

b)

B-aminoisobutyrate

c)

Ammonia

d)

None of the options

8.

Breakdown of hypoxanthine and guanine is similarly catalyzed by an enzyme called

(a)