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Cell signalling GPCRs

Total questions: 11

Worksheet time: 8mins

Name
Class
Date
1.
GPCRs are also called ___ receptors
a)
7TM
b)
ATM
c)
7AM
d)
GTM
2.

In the cAMP-PKA pathway, ___ is the effector protein.

a)

cAMP

b)

Protein Kinase A

c)

Adenylyl cyclase

d)

Phospholipase C

3.
Increase in cAMP activates the transcription of specific genes that contain a regulatory sequence called the ___.
a)
cAMP response element
b)
cGMP response element
c)
CREB
d)
Direct repeat element
4.
Diacylglycerol is hydrophilic and enters the cytoplasm.
a)
True
b)
False
5.
cGMP is a second messenger
a)
True
b)
False
6.

Rearrange the steps involved in the initiation of Ca2+ flux by Epinephrine.

a)

Kinases converts phosphatidylinositol (PI) to PIP2

b)

Phospholipase C catalyzes cleavage of PIP2 to DAG & IP3

c)

Inositol trisphosphate (IP3) binds to ligand-gated Ca2+ channels

d)

Ca2+ is released from intracellular stores in the SER and mitochondria

1)
2)
3)
4)
7.
___ family members contain Gα subunits that activate PLC-β.
a)
Gq
b)
Gs
c)
Gi
d)
G13
8.

Which enzyme is activated by cAMP in the signaling pathway?

a)

Protein kinase A

b)

Phospholipase C

c)

Glycogen synthase

d)

Adenylyl cyclase

9.

What is the primary function of phospholipase C in cell signaling?

a)

To phosphorylate glycogen synthase

b)

To degrade cAMP

c)

To produce inositol trisphosphate

d)

To activate protein kinase A

10.

Which G protein subunit is primarily involved in activating adenylyl cyclase?

a)

Gi

b)

Gs

c)

Gq

d)

G12

11.

Excited Rhodopsin activates the G Protein named (a)