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Drugs for Bronchial Asthma, RA and Gout

Total questions: 15

Worksheet time: 4mins

Name
Class
Date
1.

Which of the following drugs is useful in asthma because it stabilizes mast cells?

a)

Salbutamol

b)

Cromolyn

c)

Ipratropium

d)

Theophylline

2.

A 13-year-old boy with severe asthma has been treated for 6 months with good control of nocturnal wheezing. His parents now complain that he seems to be very fat around the face and shoulders, bruises easily, and has discolored streaks on his abdomen. Laboratory tests reveal moderate hyperglycemia. He has probably been receiving which of the following drugs?

a)

ipratropium

b)

prednisone

c)

salmeterol

d)

terbutaline

3.

Which of the following is the drug of choice to reverse bronchoconstriction in an acute asthma attack?

a)

Salbutamol

b)

Aminophylline

c)

Salmeterol

d)

Ipratropium

4.

The most prominent and dose related side effect of

salbutamol is:

a)

Rise in blood pressure

b)

Muscle tremor

c)

Hyperglycaemia

d)

Central nervous system stimulation

5.

Select the fastest-acting inhaled bronchodilator:

a)

Ipratropium bromide

b)

Formoterol

c)

Salbutamol

d)

Salmeterol

6.

Select the correct statement about salmeterol:

a)

It is a long acting selective β2 agonist bronchodilator

b)

It is a bronchodilator with anti-inflammatory

property

c)

It is a β blocker that can be safely given to

asthmatics

d)

It is an antihistaminic with mast cell stabilizing

property

7.

Select the most appropriate drug for regular prophylactic therapy in a 10 year old child who suffers from exercise induced asthma:

a)

Oral salbutamol

b)

Oral theophylline

c)

Inhaled sodium cromoglycate

d)

Inhaled salmeterol

8.

Select the drug that is neither bronchodilator nor anti-inflammatory, but has antihistaminic and mast cell stabilizing activity:

a)

Sodium cromoglycate

b)

Ketotifen

c)

Beclomethasone

d)

Montelukast

9.

Leukotriene antagonists are used in bronchial asthma:

a)

For terminating acute attacks

b)

As monotherapy in place of β2 agonists

c)

As nebulized powder in refractory cases

d)

As adjuvants to β2 agonists for avoiding

corticosteroids

10.

Choose the correct statement about theophylline:

a)

Its use in asthma has declined because of

narrow safety margin

b)

Its dose needs to be reduced in smokers

c)

It acts by increasing the formation of cAMP

d)

Its plasma halflife is longer in children compared

to that in adults

11.

Identify the first line disease modifying antirheumatic drugs.

a)

Anakinra

b)

Hydroxychloroquine

c)

Prednisolone

d)

Methotrexate

12.

A woman with RA planning pregnancy asks about medication safety. Which drug is contraindicated in pregnancy because of teratogenicity?

a)

Hydroxychloroquine

b)

Sulfasalazine

c)

Methotrexate

d)

Prednisone (low dose)

13.

The selective COX-2 inhibitors have the following

advantage(s) over the nonselective NSAIDs:

a)

They have more potent analgesic effects.

b)

They are not likely to produce renal

complications

c)

They are likely to be more effective in

rheumatoid arthritis

d)

They are less likely to cause gastric ulcers

and their complications

14.

A 55-year-old man presents with acute monoarticular pain of the first metatarsophalangeal joint starting 12 hours ago. Which of the following is first-line pharmacologic therapy for acute gout attack in a patient with no contraindications?

a)

Allopurinol

b)

Indomethacin

c)

Probenecid

d)

Febuxostat

15.

Which adverse effect is most characteristically associated with chronic colchicine therapy?

a)

Hepatotoxicity with elevated transaminases

b)

Dose-related GI upset and diarrhea

c)

Hypoglycemia

d)

Agranulocytosis